内科治疗对肝硬化患者血清胃动素,肽YY,IgG和铁蛋白的影响

目的 :研究内科治疗对肝硬化患者血清胃动素 (MTL) ,肽YY(PYY) ,IgG和铁蛋白 (FRT)的影响。方法 :临床确诊的肝硬化患者 78例 ,按病因分为乙型肝炎后 (HbsAg阳性 ) 61例 ,丙型肝炎后 (HCV抗体阳性 ) 5例 ,酒精性 4例和原因不明 8例 ;Child分级为A级 2 3例 ,B级 39例和C级 1 6例。并选 2 7例无肝胆胰及内分泌疾病者作对照。结果 :与对照比较 ,肝硬化患者血清MTL ,PYY ,IgG和FRT均明显升高 (P <0 .0 1 ) ,且与肝功能损伤程度有关。经内科治疗 4周后 (n =70 )血清MTL ,PYY和IgG均有下降 (P <0 .0 5) ,而FRT下降不明显 (P >0 .0 5)。结论 :本组肝硬化患者血清MTL ,PYY ,IgG和FRT有明显升高 ,经内科治疗可改善

Serum motilin,peptide YY,IgG and ferritin in patients with hepatic cirrhosis

Objective: To investigate the changes of serum motilin(MTL),peptide YY(PYY),immunoglobulin G(IgG) and ferritin (FRT) in patients with hepatic cirrhosis before and after internal therapy.Methods: This investigation was conducted on 78 patients with hepatic cirrhosis, including patients with HBsAg positive ( n =61),HCV antibody positive( n =5), alcoholic liver disease ( n =4) and others( n =8). According to Child grading,23 patients were Grade A, 39, Grade B and 16, Grade C. Before the treatment and 4 weeks after the treatment, fasting blood samples were collected in dry tubes. Serum MTL,PYY,IgG and FRT were measured with radioimmunoassay kit.Results: Serum levels of MTL,PYY ,IgG and FRT were significantly higher than those in normal subjects ( P <0.01).Four weeks after therapy( n =70),serum MLT,PYY and IgG were decreased ( P <0.05, respectively), while FRT remained unchanged( P >0.05). Conclusion: Our data show that serum levels of MTL,PYY, IgG and FRT are increased in patients with hepatic cirrhosis and can be improved after therapy.