| 大鼠实验性长期糖尿病周围神经病的诱发及其形态学观察 |
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| 引用本文： | 卫重娟,程焱. 大鼠实验性长期糖尿病周围神经病的诱发及其形态学观察[J]. 天津医药, 2003, 31(12): 783-785 |
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| 作者姓名： | 卫重娟 程焱 |
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| 作者单位： | 1. 300052,天津医科大学总医院高干病房
2. 300052,天津医科大学总医院神经内科 |
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| 摘 要： | 目的：制备大鼠实验性长期糖尿病周围神经病(DNP)模型，观察其周围神经的形态学改变。方法：链脲佐菌素(STZ)注射造模后维持5个月，电镜下观察腓肠神经超微结构改变，光镜下计数有髓神经纤维。结果：STZ糖尿病大鼠出现了血糖及糖化血红蛋白升高、体重下降和多食多饮多尿，周围神经出现了髓鞘明显变性即髓鞘板层结构破坏和瓦勒氏变性，但有髓神经纤维计数无明显变化。结论：模型成功地维持了5个月，STZDNP大鼠周围神经主要形态学改变为髓鞘变性。
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| 关 键 词： | 大鼠 实验 糖尿病 周围神经病 形态学 动物模型 |
Establishment of Rat Model of Long-term Experimental Diabetic Neuropathy and Its Morphological Changes |
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| WEI Chongjuan,CHENG Yan Tianjin Medical University hospital,Tianjin China. Establishment of Rat Model of Long-term Experimental Diabetic Neuropathy and Its Morphological Changes[J]. Tianjin Medical Journal, 2003, 31(12): 783-785 |
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| Authors: | WEI Chongjuan CHENG Yan Tianjin Medical University hospital Tianjin China |
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| Affiliation: | WEI Chongjuan,CHENG Yan Tianjin Medical University hospital,Tianjin 300052 China |
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| Abstract: | Objective:To prepare the rat model of long-term experimental diabetic neuropathy and observe the morphological changes of the peripheral nerve. Methods:After STZ injection, the rats had been raised for 5 months and then the ultrastrutural changes of sural nerve were observed under the electron microscope and the number of myelinated nerve fibers was counted under the light microscope. Results:Hyperglycemia,HbA1c_raising,bodyweight_losing,over_eating,over_drinking and polyiria developed in STZ_treated diabetic rats.Marked degeneration of myelin and Wallerian degeneration could be observed, though withought changes in the number of myelinated nerve fibers.Conclusion:The rat model of DNP was raised for 5 months successfully and the main morphological changes were degeneration of myelin. |
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| Keywords: | diabetic neuropathies streptozocin rats |
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