甲氨蝶呤联合中药治疗类风湿性关节炎的疗效观察

目的探讨甲氨蝶呤联合中药治疗类风湿性关节炎（RA）的临床疗效。方法2005年1月—2009年1月,120例RA患者随机分为两组,观察组60例,采用甲氨蝶呤联合中药治疗;对照组60例采用单纯甲氨蝶呤治疗,比较两组的临床疗效及主要症状、体征与实验室指标。结果观察组治疗的总有效率明显高于对照组,两组比较差异有统计学意义（P〈0.05）。与治疗前比较,两组治疗后晨僵时间、20m步行时间、血沉及类风湿因子水平均明显下降,双手握力明显增高,差异有统计学意义（P〈0.05）。观察组治疗后晨僵时间、双手握力、20m步行时间、血沉及类风湿因子水平均优于同期对照组水平,两组比较差异有统计学意义（P〈0.05）。结论甲氨蝶呤联合正清风痛宁缓释片治疗RA,效果好,是治疗RA较为理想的联合治疗方案。

The Effect Observation of Methotrexate Combined with Traditional Chinese Drug in Treatment with Rheumatoid Arthritis

OBJECTIVE To observe the clinical effect of methotrexate combined with traditional Chinese drug in treatment with rheumatoid arthritis （RA） . METHOD From January 2005 to January 2009, 120 cases of RA patients were classified into two groups, which observation group with 60 cases were treated with methotrexate combined with traditional Chinese drug and control group with 60 cases were treated with methotrexate. The clinical efficacy and cardinal symptom, objective sign and laboratory indexes were observed and compared between the two groups. RESULTS The total effective rate in observation group was significantly higher than that in control group （P〈0.05） . Compared with pre-treatment, the morning stiffness time, 20m walking time, ESR and RF were significantly decreased （P〈0.05） and hand grip was significantly increased （P〈0.05） in both two groups after treatment. Moreover, After treatment, the morning stiffness time, hand grip, 20m walking time, ESR and RF in observation group was significantly better than those in control group （P〈0.05） . CONCLUSION Methotrexate combined with traditional Chinese drug in treatment with RA can enhance effective rates and improve cardinal symptom, objective sign and laboratory indexes, which is an idea method.