| 银屑病发病机制中免疫学研究进展 |
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| 引用本文： | 叶晓敏,陆春. 银屑病发病机制中免疫学研究进展[J]. 国际皮肤性病学杂志, 2010, 36(4). DOI: 10.3760/cma.j.issn.1673-4173.2010.04.009 |
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| 作者姓名： | 叶晓敏 陆春 |
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| 作者单位： | 中山大学附属第三医院皮肤科,广州,510630 |
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| 摘 要： | 银屑病的发病机制与免疫关系密切,近几年研究倾向于银屑病是Th1/Th17混合途径的免疫性疾病.银屑病的发病中除了有树突细胞、T细胞、角质形成细胞以及Tb1型的细胞因子如白介素12、白介素18等参与外,还有Th17型细胞因子,如白介素23及白介素22等的参与,Th17型免疫反应可能在银屑病发病中起到重要的作用.
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| 关 键 词： | 银屑病 免疫学 细胞因子类 |
Immunological advances in pathogenesis of psoriasis |
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| YE Xiao-min,LU Chun. Immunological advances in pathogenesis of psoriasis[J]. International Journal of Dermatology and Venereology, 2010, 36(4). DOI: 10.3760/cma.j.issn.1673-4173.2010.04.009 |
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| Authors: | YE Xiao-min LU Chun |
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| Abstract: | The pathogenesis of psoriasis is closely associated with immune system. Most of recent studies have suggested that psoriasis is a mixed Thl/Thl7 immunological disease. Besides dendritic cells, T cells, keratinocytes and Thl type cytokines such as interleukin (IL)-12 and IL-18, Thl7 type cytokines such as IL-23 and IL-22 also participate in the development of psoriasis. Thl7 type immune response may play an essential role in the pathogenesis of psoriasis. |
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| Keywords: | Psoriasis Immunology Cytokines |
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