| 金属粉末注射成型制备316L不锈钢植入材料 |
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| 引用本文： | 王国慧,朱晒红,李益民,赵颜忠,周科朝,黄伯云.金属粉末注射成型制备316L不锈钢植入材料[J].生物医学工程学杂志,2007,24(2):329-331. |
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| 作者姓名： | 王国慧 朱晒红 李益民 赵颜忠 周科朝 黄伯云 |
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| 作者单位： | 1. 中南大学,湘雅三医院,移植医学研究院,长沙,410013
2. 中南大学,粉末冶金国家重点实验室,长沙,410083 |
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| 基金项目： | 国家高技术研究发展计划(863计划);中南大学校科研和教改项目 |
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| 摘 要： | 研究金属粉末注射成型(MIM)法制备的316L不锈钢植入材料的生物相容性。以目前临床应用的钛合金植入材料为对照,将MIM法制备的植入材料浸提液与L929细胞混合培养后用流式细胞仪测定其DNA期的细胞百分比,将二种材料分别植入动物体内通过病理组织学观察的方法来评价其生物相容性。统计学分析两组数据无明显差异,结果表明,MIM法制备的316L不锈钢植入材料具有良好的生物相容性。
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| 关 键 词： | 金属粉末注射成型 生物相容性 流式细胞仪 |
| 修稿时间： | 2005-05-082005-07-28 |
Study on Biocompatibility of MIM 316L Stainless Steel |
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| Wang Guohui,Zhu Shaihong,Li Yiming,Zhao Yanzhong,Zhou Kechao,Huang Boyun.Study on Biocompatibility of MIM 316L Stainless Steel[J].Journal of Biomedical Engineering,2007,24(2):329-331. |
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| Authors: | Wang Guohui Zhu Shaihong Li Yiming Zhao Yanzhong Zhou Kechao Huang Boyun |
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| Institution: | 1.Transplantation Medical Academy, Third XiangYa Hospital, Central South University,Changsha 410013,China; 2.State Key Laboratory for Powder Metallurgy, Central South University,Changsha 410083,China |
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| Abstract: | This study was aimed to evaluate the biocompatibility of metal powder injection molding (MIM) 316L stainless steel. The percentage of S-period cells was detected by flow cytometry after L929 cells being incubated with extraction of MIM 316L stainless steel,and titanium implant materials for clinical application were used as control. In addition, both materials were implanted in animals and the histopathological evaluations were carried out. The statistical analyses show that there are no significant differences between the two groups(P> 0. 05), which demonstrate that MIM 316L stainless steel has good biocompatibility. |
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| Keywords: | Metal powder injection molding (MIM) Biocompatibility Flow cytometry |
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