Genetic polymorphisms of <Emphasis Type="Italic">FSHR,CYP17, CYP1A1, CAPN10, INSR,SERPINE1</Emphasis> genes in adolescent girls with polycystic ovary syndrome |
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Authors: | Tugba Unsal Ece Konac Ediz Yesilkaya Akin Yilmaz Aysun Bideci Hacer Ilke Onen Peyami Cinaz Adnan Menevse |
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Institution: | (1) Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, 6500 Ankara, Turkey;(2) Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey |
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Abstract: | Background Polycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, is the most common endocrine disorder
in women and it typically develops during adolescence. The aim of this study is to investigate the possible association between
single nucleotide polymorphisms (SNPs) of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and PCOS in adolescent girls.
Methods DNA samples from forty-four adolescent girls with PCOS and 50 healthy controls were analyzed by PCR-RFLP and direct DNA sequencing
to determine the genotypic frequency of 17 different polymorphic loci on the FSHR (A307T, N680S), CYP17 (−34 T/C), CYP1A1 (T6235C), CAPN10 (44, 43, 19, 63), INSR (exon 17 C/T), SERPINE1 (4G/5G) genes. Genotyping of exon 12 (six polymorphisms) and intron 12 (one polymorphism) of INSR gene by direct DNA sequencing was performed for the first time in this study.
Results No significant differences were observed in the genotype and allele distributions of above mentioned polymorphisms between
cases and control groups.
Conclusion Our data does not support an association between SNPs of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and susceptibility to PCOS or related traits in Turkish adolescent girls. |
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Keywords: | Adolescent girl Genetic polymorphisms Polycystic ovary syndrome |
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