| 3,5-二氯-4-吡啶酮乙酸的合成 |
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| 引用本文： | 张环宇,曲有乐,周淑晶. 3,5-二氯-4-吡啶酮乙酸的合成[J]. 黑龙江医药科学, 2006, 29(1): 41-41 |
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| 作者姓名： | 张环宇 曲有乐 周淑晶 |
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| 作者单位： | 1. 佳木斯大学化学与药学院,黑龙江,佳木斯,154007
2. 浙江海洋学院,浙江,定海,316000 |
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| 摘 要： | 目的:以4-吡啶酮为原料,合成头孢西酮中间体3,5-二氯-4-吡啶酮乙酸.方法:4-吡啶酮与次氯酸钠迅速合成3,5-二氯-4-吡啶酮,再与一氯乙酸脱HCl制得3,5-二氯-4-吡啶酮乙酸.结果:制得3,5-二氯-4-吡啶酮乙酸.结论:该方法合成的目标产物纯度99.5%,收率89%.
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| 关 键 词： | 3,5-二氯-4-吡啶酮乙酸 头孢西酮 |
| 文章编号： | 1008-0104(2006)01-0041-01 |
| 修稿时间： | 2005-12-21 |
Synthesis of 3,5-dichloro-4-pyridon-1-acetic acid |
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| ZHANG Huan-yu,QU You-le,ZHOU Shu-jing. Synthesis of 3,5-dichloro-4-pyridon-1-acetic acid[J]. Heilongjiang Medicine and Pharmacy, 2006, 29(1): 41-41 |
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| Authors: | ZHANG Huan-yu QU You-le ZHOU Shu-jing |
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| Abstract: | Objective: To synthesize of 3,5-dichloro-4-pyridon-1-acetic acid.Method: 3,5-dichloro-4-pyridon was rapidly synthesized with 4-pyridon and sodium hypochlorite, and then 3,5-dichloro-4-pyridon-1-acetic acid was prepared synthesized from 4-pyridone, ethyl chloroacetate reduction(-HCL).Results: 3,5-dichloro-4-pyridon-1-acetic acid was synthesized. Conclusion:The synthesis method has the advantages of low cost ,high yield and better product purity , suitable for industry. |
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| Keywords: | 3 5-dichloro-4-pyridon-1-acetic acid cefazedone |
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