| 2，6－哌嗪二酮类抗肿瘤药物的研究1－取代苯基－4－（2′，3′－二乙酰氧基－5′－甲氧羰基苄基）－2，6－哌嗪二酮的合成 |
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| 引用本文： | 李全,沈旭,蒋华良,谢毓元.2，6－哌嗪二酮类抗肿瘤药物的研究1－取代苯基－4－（2′，3′－二乙酰氧基－5′－甲氧羰基苄基）－2，6－哌嗪二酮的合成[J].中国药物化学杂志,1995(3). |
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| 作者姓名： | 李全 沈旭 蒋华良 谢毓元 |
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| 作者单位： | 中国科学院上海药物研究所 |
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| 摘 要： | 本文设计合成了１１个１－取代苯基－４－（２′，３′－二乙酰氧基－５′－甲氧羰基苄基）－２，６－哌嗪二酮类化合物，并经对小鼠白血病细胞Ｐ３８８、小鼠肝癌细胞Ｈｅｐ和人体胃癌细胞ＳＧＣ７９０１的体外实验表明，化合物９ｊ对Ｐ３８８白血病细胞有较强的抑制作用，化合物９ｄ对Ｈｅｐ肝癌细胞有较强的抑制作用。本文还考察了超声波辐射时间对Ｍａｎｎｉｃｈ反应的影响。
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| 关 键 词： | 1－取代苯基－4－（2′．3′－二乙酰氧基－5′－甲氧羰基苄基）－2．6－哌嗪二酮 体外抗肿瘤试验 |
Studies on Synthesis and Antitumor Activity of 1-Substituted -4-(2',3'-Diacetoxy-5'-Carbomethoxy Benzyl)-2,6-Piperazinediones |
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| Li Quan,Shen Xu,Jiang Hualiang,Xie Yuyuan.Studies on Synthesis and Antitumor Activity of 1-Substituted -4-(2',3'-Diacetoxy-5'-Carbomethoxy Benzyl)-2,6-Piperazinediones[J].Chinese Journal of Medicinal Chemistry,1995(3). |
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| Authors: | Li Quan Shen Xu Jiang Hualiang Xie Yuyuan |
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| Abstract: | In searching for effective new antitumor drugs,eleven compounds with the structure of 1-substituted-4-(2',3'-diacetoxy-5-'carbomethoxybenzyl)-2,6-piperazinediones were synthesized. Their antitumor activities on P388 cells,Hep cells and SGC 7901 cells in vitro were tested.Preliminary results showed that the compound(9j)was moderately effective against P388 cells and the compound (9d)seemed effective against Hep cells.The effect of ultraosonic wave on the Mannich reaction was also studied. |
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| Keywords: | Substituted-4-(2' 3'-diacetoxy-5'-carbomethoxybenzyl)-2 6-piperazinediones Antitumor activity in vitro |
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