| 乳腺癌与微卫星不稳定性的相关研究 |
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| 引用本文： | 刘国辉,姚永华,王权,所剑. 乳腺癌与微卫星不稳定性的相关研究[J]. 内分泌外科杂志, 2011, 0(3): 165-166,178 |
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| 作者姓名： | 刘国辉 姚永华 王权 所剑 |
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| 作者单位： | 吉林大学第一医院晋外科,长春130021 |
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| 摘 要： | 目的探索乳腺癌微卫星不稳定性（MSI）与临床特征的相关性。方法收集60例乳腺癌组织标本，选择5个微卫星多态性标记（位点），DNA的提取，PCR扩增，电泳，EB显色后进行MSI分析。结果乳腺癌MSI发生率为33．3％，正常乳腺组织MSI发生率为0，乳腺癌MSI与分化程度有关。结论MSI是乳腺癌发生的早期分子生物学事件，可作为判断乳腺癌恶性程度及预后的指标。
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| 关 键 词： | 乳腺癌 微卫星不稳定性 |
Correlation between breast cancer and microsatellite instability |
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| LIU Guo-hui,YAO Yong-hua,WANG Quan,SUO Jian. Correlation between breast cancer and microsatellite instability[J]. , 2011, 0(3): 165-166,178 |
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| Authors: | LIU Guo-hui YAO Yong-hua WANG Quan SUO Jian |
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| Affiliation: | . Department of General Surgery, the First Affiliated Hospital, Jilin University, Chaugchun 130021, China |
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| Abstract: | Objective To investigate the correlation between clinical features of breast cancer and microsatellite instability （MSI）. Methods 60 samples of breast cancer were collected and 5 microsatellite polymorphisrn loci were selected. MSI analysis was made after DNA isolation, PCR amplification, electrophoresis and EB staining. Results The rate of MSI was 33.3% in breast cancer and 0% in normal breast tissues. MSI in breast cancer was associated with carcinoma differentiation degree. Conclusion MSI is an early event during breast carcinogenesis and it plays an important role in estimation of malignant degree. |
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| Keywords: | Breast cancer Microsatellite instability |
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