基因治疗在创伤愈合中的应用

创伤修复是一个复杂的生物学过程,各种生长因子、炎症介质等在创面愈合过程中扮演着重要角色。基因治疗是现代生物治疗的一项重要技术,在创伤修复,尤其是难愈性创面的治疗中具有广阔的应用前景。基因治疗分为病毒载体导入系统（逆转录病毒、慢病毒、腺病毒、单纯疱疹病毒和腺病毒相关病毒等）和非病毒载体导入系统的基因感染（直接注射、显微注射、基因枪、电穿孔、脂质体和脂质体复合物、阳离子多聚物等）。本文对创伤修复及基因治疗在该领域的应用进行文献综述。

Gene therapy in wound healing applications

Wound healing is a complex biological process, during which various growth factors, inflammatory mediators, and so on, play an important role. Gene therapy is an important technology in modern biological treatment. In the future, gene therapy wiu have a widely application prospects in the treatment of wound healing, especially non-healing wounds. Gene therapy could be realized via viral vector transfer system （Retrovirus, lentivirus, adenovirus, herpes simplex virus and adeno-associated virus, etc）, or non-viral vector transfer system （direct injection, microinjection, gene gun, electroporation, liposomes and liposome complexes, cationic polymers, etc）. In this paper, the applications of gene therapy in wound healing will be reviewed.