湖北省2005年预防接种副反应监测分析

目的 开展预防接种副反应试点监测，探寻预防接种副反应监测的有效方法。方法 建立全省预防接种副反应监测报告网，通过中国免疫规划监测信息管理系统逐级报告预防接种副反应，并做好监测结果的评估与分析。结果 全省22个县市报告预防接种副反应，报告接种副反应57例。分类属疫苗反应37例（64．91％）。偶合症10例（17．54％），原因不明或待定9例（15．78％）。实施差错1例（1．75％）。临床诊断为过敏反应18例（31．58％），发热18例（31．58％），病因不明9例（15．79％），上呼吸道感染4例（7．02％），卡介苗接种加重反应3例（5．26％），病毒性脑炎3例（5．26％）。瘢痕反应和接种部位错误各1例（3．51％）。年龄〈1岁21人（36．84％）。1—5岁29人（50．88％）。10—20岁5人（8．77％）。30—50岁1人（1．75％）。不详1人（1．75％）。接种与反应间隔时间。在0—3d 50例（87．7％）。15d以上7例（12．3％）。结论 开展预防接种剐反应监测是免疫规划工作的重要内容之一，本次监测试点方案可操作性强。监测系统进一步完善后可考虑全面推行。

Monitoring of adverse reactions in prophylactic vaccination in Hubei Province in 2005

Objective To monitor adverse reactions due to vaccination.Methods The monitoring - and - vaccination-asso- ciated adverse-reaction-reporting network was established in whole Hubei Province and the vaccination - associated adverse reac- tions were monitored and reported from lower level to higher level through China expanded immunization program monitoring informa- tion system.Results Vaccination-associated adverse reactions were reported in 22 counties and cities and 57 cases were report- ed,including 37 cases due to vaccination(64.91%),10 coincident cases (17.54%),9 unknown causes (15.78%),1 mistaken case(1.75%).Based on clinical diagnosis,18 were diagnosed as allergic reaction (31.58),18 were diagnosed as fever(31. 58%),9 were unidentified 15.78%),4 were diagnosed as upper respiratory tract infection (7.02%),3 were diagnosed as BCG re- action(5.26%),3 were diagnosed as viral encephalitis(5.26%) and the other 2 were scar reaction and wrong vaccination site (3. 51%).About 87.72% of adverse reactions occurred in the age groups of 1-5 years old and 87.7% of the adverse reactions were observed from 0 to 3 days after vaccination.Conclusion The work of monitoring vaccination associated adverse reactions is one of the important task of EPI and be carried out after pilot trial.