| A case of Klinefelter’s syndrome with type 1 diabetes mellitus |
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| 引用本文： | Cai XP,Zhao L,Mao M,Yang ZJ,Xing XY,Li GW. A case of Klinefelter’s syndrome with type 1 diabetes mellitus[J]. 中华医学杂志(英文版), 2012, 125(5): 937-940 |
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| 作者姓名： | Cai XP Zhao L Mao M Yang ZJ Xing XY Li GW |
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| 摘 要： | Klinefelter’s syndrome (KS) is the most common sex chromosome disease in men. Classical features of the syndrome include a eunuchoidal body habitus, small testes and hypergonadotrophic hypogonadism. There has been an increased risk of diabetes mellitus and autoimmune disease for KS patients. This paper reports a case of KS in association with type 1 diabetes mellitus. The patient was a 21-year-old man, who has been confirmed by absolute insulin deficiency and positive IA-2 autoantibody. The hyperinsulinemic euglycemic clamp test indicated his insulin sensitivity in normal range, and his blood glucose was controlled well by the insulin therapy.
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| 关 键 词： | Klinefelter’s syndrome type 1 diabetes mellitus autoimmune |
A case of Klinefelter's syndrome with type 1 diabetes mellitus |
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| Cai Xiao-pin,Zhao Li,Mao Min,Yang Zhao-jun,Xing Xiao-yan,Li Guang-wei. A case of Klinefelter's syndrome with type 1 diabetes mellitus[J]. Chinese medical journal, 2012, 125(5): 937-940 |
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| Authors: | Cai Xiao-pin Zhao Li Mao Min Yang Zhao-jun Xing Xiao-yan Li Guang-wei |
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| Affiliation: | Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, and Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100730, China. |
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| Abstract: | Klinefelter’s syndrome (KS) is the most common sex chromosome disease in men. Classical features of the syndrome include a eunuchoidal body habitus, small testes and hypergonadotrophic hypogonadism. There has been an increased risk of diabetes mellitus and autoimmune disease for KS patients. This paper reports a case of KS in association with type 1 diabetes mellitus. The patient was a 21-year-old man, who has been confirmed by absolute insulin deficiency and positive IA-2 autoantibody. The hyperinsulinemic euglycemic clamp test indicated his insulin sensitivity in normal range, and his blood glucose was controlled well by the insulin therapy. |
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