CD31、CD34和CD105在舌鳞癌微血管中的表达及其与颈淋巴结转移的关系

目的探讨CD31、CD34和CD105在舌鳞癌微血管中的表达及其与颈淋巴结转移的关系。方法采用免疫组织化学SP法对40例舌鳞癌组织标本进行标记染色，按Weidner法计算CD31、CD34和CD105标记的肿瘤组织微血管密度（MVD）。结果CD31、CD34和CD105在舌癌组织区的表达明显高于正常区组织（P<0.01），CD31与CD34标记的MVD值相比较差异无统计学意义（P>0.05），而它们与CD105之间差异有统计学意义（P<0.01）。不同血管标记物标记的舌癌组织MVD值在男、女患者之间差异无统计学意义（P>0.05），CD31、CD34标记的MVD值在不同的病理分级、临床分期之间差异没有统计学意义（P>0.05），CD105标记的MVD值在不同的病理分级、临床分期之间差异有统计学意义（P<0.05）。不同血管标记物标记的舌癌组织MVD值在有或无淋巴结转移之间差异具有统计学意义（P<0.05），而CD105组差异更为显著（P<0.01）。结论CD105是一种更为理想的血管内皮细胞标记物，它能够更为准确地提示患者发生转移的可能性，可能与舌癌的发生发展有密切的关系。

Expression of CD31,CD34 and CD105 in squamons cell carcinoma of tongue and their relationships with lymph node metastasis

Objective To research the expression of CD31,CD34 and CD105 in squamous cell carcinoma of tongue(TSCC) and discuss their relationships with lymph node metastasis.Methods All the specimens' segments were stained by immunohistochemical method SP,and then the tumor's microvessel density(MVD) marked by CD31,CD34 and CD105 were counted by the Weidner's method.Results The expression of CD31,CD34 and CD105 in the tumor's tissue was much higher than that in the normal tissue(P<0.01).There was no obvious difference between the MVD values marked by CD31 and CD34(P>0.05),but they were obviously different from which marked by CD105(P<0.01).The MVD values between the male and female patients had no statistical difference(P>0.05).The MVD values marked by CD31 and CD34 had no statistical difference in different pathological grades and clinical stages(P>0.05),but there was statistical difference in different pathological grades and clinical stages marked by CD105(P<0.05).Although the MVD value of the cases with lymph node metastasis was different from that without metastasis marked by CD31 and CD34(P<0.05),there was much higher difference between the cases with lymph node metastasis and those without metastasis marked by CD105(P<0.01).Conclusion CD105 is a more satisfying vascular endothelial marker than others.It can predict the metastasis possibility of the TSCC patients,thus it may be particularly important in the development of TSCC.