| SARS-CoV病毒抗体对恒河猴SARS-CoV的感染保护作用 |
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| 引用本文： | 秦川 魏强 高虹 蒋虹 涂新民 邓巍 丛喆 李国生 张连峰 Yasuhiro Yashikawa.SARS-CoV病毒抗体对恒河猴SARS-CoV的感染保护作用[J].中国比较医学杂志,2005,15(6):323-326. |
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| 作者姓名： | 秦川 魏强 高虹 蒋虹 涂新民 邓巍 丛喆 李国生 张连峰 Yasuhiro Yashikawa |
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| 作者单位： | 1. 中国医学科学院,中国协和医科大学实验动物研究所,北京,100021
2. Department of Biomedical Science ,Faculty of Agriculture, The University of tokyo,113-8657,Japan |
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| 基金项目： | “863”课题,编号：2003AA208205;2003AA208213. |
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| 摘 要： | 目的研究了实验感染产生中和抗体以及输入SARS-CoV中和抗体对SARS-CoV感染恒河猴的保护作用。方法动物分3组，分别为SARS感染恢复动物组，输入抗SARS阳性血清动物组和SARS模型对照组，分别接种病毒，1—7d进行病毒检测和血清学检测，7d后安乐处死动物，进行病理检测。结果实验感染产生中和抗体，输入SARS-CoV中和抗体的恒河猴体内SARS-CoV复制得到一定程度的抑制，病理变化也比模型组轻。结论SARS—CoV中和抗体（包括被动免疫）是一种有潜力的SARS治疗方法。
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| 关 键 词： | SARS-CoV 恒河猴 中和抗体 保护实验 |
| 文章编号： | 1671-7856（2005）06-0323-04 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005年9月12日 |
Protective Effect of Anti-SARS-CoV Antibody on SARS-CoV Infection in Macaca Mulatta |
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| QIN Chuan,WEI Qiang,Gao Hong,Jiang Hong,Tu Xin-min,Deng Wei,Cong Zhe,Li Guo-sheng,ZHANG Lian-feng,Yasuhiro Yashikawa.Protective Effect of Anti-SARS-CoV Antibody on SARS-CoV Infection in Macaca Mulatta[J].Chinese Journal of Comparative Medicine,2005,15(6):323-326. |
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| Authors: | QIN Chuan WEI Qiang Gao Hong Jiang Hong Tu Xin-min Deng Wei Cong Zhe Li Guo-sheng ZHANG Lian-feng Yasuhiro Yashikawa |
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| Abstract: | Objective The SARS is an infectious disease which was newly conformed in China. The effective clinical treatment for this disease is still being under studying, The aim of the present study was to investigate the protective effect of antiSARS-CoV antibody on SARS-CoV infection in Macaca mulatta monkey model. Methods To analyze changes of anti-SARS-CoV antibody treated SARS-monkeys. Results The aquired neutralization antibody for SARS-CoV inhibited the replication of the virus to a certain extent. The pathological changes of the antibody treatment group were lighter than those in the SARS-monkey group. Conclusions Our findings suggested that anti-SARA-CoV neutralization antibody therapy is a potentially useful clinical treatment for SARS. |
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| Keywords: | SARS-CoV Rhesus monkey Neutralization antibodies |
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