| 泪腺良性淋巴上皮病变的病因及发病机制 |
| |
| 引用本文： | 王霄娜,马建民. 泪腺良性淋巴上皮病变的病因及发病机制[J]. 国际眼科纵览, 2014, 0(3): 208-211 |
| |
| 作者姓名： | 王霄娜 马建民 |
| |
| 作者单位： | 首都医科大学附属北京同仁医院北京同仁眼科中心眼科学与视觉科学北京市重点实验室,100730 |
| |
| 基金项目： | 国家自然科学基金（81170875）;北京市卫生系统高层次卫生技术人才培养计划（2011-3-041） |
| |
| 摘 要： | 良性淋巴上皮病变以双侧或单侧泪腺、眼睑肿胀和（或）涎腺弥漫性无痛性肿大为主要临床表现.目前该病具体病因及发病机制尚未阐明.从病理学、感染学、免疫学、流行病学、分子生物学等多方面对该病的病因及发病机制进行总结,良性淋巴上皮病变的病因主要包括基底细胞增生浸润、病毒诱导、自身免疫功能障碍、性激素紊乱、蛋白紊乱、IgG4浸润等假说.这些假说都可以从不同侧面对良性淋巴上皮病变的病因及发病机制进行解释,但仍存一定争议,有待更深入研究,以便指导临床诊断及治疗.
|
| 关 键 词： | 良性淋巴上皮病变 病因学 基底细胞增生浸润 病毒诱导 自身免疫障碍 |
The etiology and pathogenesis of lacrimal benign lymphoepithelial lesion |
| |
| WANG Xiao-na,MA Jian-min. The etiology and pathogenesis of lacrimal benign lymphoepithelial lesion[J]. International Review of Opthalmology, 2014, 0(3): 208-211 |
| |
| Authors: | WANG Xiao-na MA Jian-min |
| |
| Affiliation: | 1.Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;) |
| |
| Abstract: | Benign lymphoepithelial lesion （BLEL） is known as Mikulicz disease.The clinical manifestation of BLEL mainly includes diffuse painless enlargement of unilateral or bilateral lacrimal gland or salivary gland.There are many different perspectives to analyze the pathogenesis including pathology,infection,immunology,epidemiology and molecular biology.Currently,the proposed theories for its etiology include basal cell hyperplasia invasion,virus intervention,autoimmune dysfunction,sex hormone dysregulation,protein disorder,and IgG4 invading etc,however still a lot of controversies.More researches need be conducted. |
| |
| Keywords: | benign lymphoepithelial lesion/etiology basal cell hyperplasia invasion virus intervention autoimmune dysfunction |
| 本文献已被 维普 等数据库收录！ |
|
