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HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations |
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| Authors: | Ann B. Begovich Rhea C. Helmuth Jorge R. Oksenberg Koichiro Sakai Takeshi Tabira Takehiko Sasazuki Lawrence Steinman Henry A. Erlich |
| Affiliation: | a Department of Human Genetics, Cetus, Corporation, 1400 Fifty-Third Street, Emeryville, California, USA e Department of Diagnostic Research Cetus Corporation, 1400 Fifty-Third Street, Emeryville, California, USA b Department of Neurology and Genetics, Stanford University, Stanford, California, USA c Division of Demyelinating Diseases and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan d Department of Genetics, Medical Institute of Bioregulation, Kyusha University, Fukuoka 812, Japan |
| Abstract: | Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DPβ locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DPβ allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease. |
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