神经衰弱患者的十年随访研究

目的　探讨神经衰弱患者的发展变化。方法　采用队列内病例对照研究 ,对 1992年诊断为神经衰弱患者十年后进行随访 ,完成随访 98例。结果　诊断改变为 4 1% ,造成诊断改变相关因素有精神病家族史、起病年龄、症状反复发作、伴躯体症状 ;8个精神病早期症状中 7个有显著性差异 (P <0 0 5 )。结论　神经衰弱患者随着时间的发展有较高的诊断改变率 ,伴有精神病早期症状的患者更易发展为精神病。

A follow-up study of neurasthenia

Objective To explore longitudinal changes in neurasthenia patients. Methods 98 neurasthenia patients were followed for ten years since 1992 in a lonqitudinal cohort study. Results 41% of all the patients had changed diagnosis during the follow-up. The factors related to changed diagnosis included family psychotic,suffer from ill age, frequent relapsing,and accompany physical symptoms. Significantly difference were found in the seven early symptoms of psychosis ( P<0.05 ). Conclusions Neurasthenia patients often changed their diagnosis during the follow-up. They were easy to devolop psychosis if the patients were accompanied by many early symptoms of psychosis.