不同年龄健康人血压和动脉顺应性关系的研究

目的:评价不同年龄健康人血压和动脉顺应性关系及其临床意义。方法:按美国明尼苏达大学方案将200名受试者分为4个年龄组:15～30岁;31～45岁;46～60岁和61～80岁。每组男女各25名,使用美国产HDI-2000动脉测试仪同步记录血压和动脉顺应性(大动脉弹性为C1,小动脉弹性为C2)。结果:男性组:收缩压(SBP)和舒张压(DBP)均随年龄增加而升高,同时C1和C2顺应性下降,有统计学意义(P均<0.01),但脉压差(PP)无统计学差异(p>0.05);C1与SBP、DBP和PP呈显著负相关,其中与SBP相关性最好(r=-0.640,P<0.01);C2与SBP和DBP呈显著负相关,其中与DBP相关性最好(r=-0.544,P<0.01),与PP无相关。女性组:SBP、DBP和PP随年龄增加而升高,C1和C2顺应性下降,有统计学差异(P均<0.01)。C1和C2均与SBP、DBP和PP呈显著负相关,其中与SBP相关性最好(r=-0.660,P<0.01;r=-0.704,P<0.01)。结论:男性和女性随着年龄的增加,大、小动脉顺应性均下降。SBP是影响其大、小动脉顺应性的最主要因素。

Relationship between Blood Pressure and Arterial Compliance in Healthy of Different Age Adults

Objective: To evaluate the clinical importance of the relation ship between blood pressure and arterial compliance in the healthy of different age. Methods: 200 healthy adults aged 15 to 80 years were divided into four groups: 15-30,31 -45,46- 60 and 61 - 80 years old. Blood pressure and arterial compliance were detected by HDI-2000. Results: In men, Systolic blood pressure (SBP) and diastolic blood pressure(DBP) increase with advancing age (P < 0. 01); C1 and C2 decreased with increasing age (P < 0.01), but pulse pressure(PP) had no significance (P > 0.05). In linear correlation analysis, C1 correlated negatively with SBP, DBP and PP, in which C1 showed the best correlation with SBP(r= -0.640, P < 0. 01); C2 correlated negatively with SBP and DBP, in which C2 showed the best correlation with DBP( r = -0. 544, P < 0. 01), but there was no correlation between C2 and PP. In women, SBP, DBP and PP increase with advancing age (P < 0. 01), C1 and C2 fell with increasing age (P < 0. 01). In linear correlation analysis, both C1 and C2 correlated negatively with SBP, DBP and PP, in which of two still showed the best correlation with SBP(r= -0.660, P < 0. 01; r= -0.704, P < 0. 01). Conclusions: Arterial compliance (C1 and C2)fell with advancing age. SBP is the main factor for large and small arterial compliances in both men and women.