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| Effect of verapamil on nitric oxide synthase in a portal veinligated rat model： Role of prostaglandin | |
| 引用本文： | Lay CS,May CM,Lee FY,Tsai YT,Lee SD,Chien S,Sinchon S. Effect of verapamil on nitric oxide synthase in a portal veinligated rat model： Role of prostaglandin[J]. World journal of gastroenterology : WJG, 2006, 12(15): 2351-2356. DOI: 10.3748/wjg.v12.i15.2351 |
| 作者姓名： | Lay CS May CM Lee FY Tsai YT Lee SD Chien S Sinchon S |
| 作者单位： | Division of Hepatology and Gastroenterology Department of Internal Medicine China Medical University Hospital,Taichung,China,Division of Gastroenterology Department of Internal Medicine,Veterans General Hospital,Taipei,National Yang-Ming University School of Medicine,Taipei,China,Division of Gastroenterology Department of Internal Medicine,Veterans General Hospital,Taipei,National Yang-Ming University School of Medicine,Taipei,China,Division of Gastroenterology Department of Internal Medicine,Veterans General Hospital,Taipei,National Yang-Ming University School of Medicine,Taipei,China,Division of Gastroenterology Department of Internal Medicine,Veterans General Hospital,Taipei,National Yang-Ming University School of Medicine,Taipei,China,Institute of Biomedical Sciences Academia Sinica,Taiwan,China,Department of Medicine Columbia University,New York University Medical Center,New York,USA |
| 摘 要： | AIM: To investigate the effects of verapamil on nitric oxide (NO) synthesis in a portal vein-ligated rat model. METHODS: Systemic and splanchnic hemodynamics were measured by radiolabeled microspheres in portal hypertensive rats after acute administration of verapamil (2 mg/kg) on chronic treatment with Nw-nitro-L-arginine (NNA)(80 mg/kg) and/or indomethacin (2 mg/kg) . RESULTS: Verapamil (2 mg/kg) caused a marked fall in both arterial pressure and cardiac output accompanied by an insignificant change in the portal pressure and no change in portal venous inflow. This result suggested that verapamil did not cause a reduction in portal vascular resistance of portal hypertensive rats, which was similar between NW- nitro-L-arginine-treated and indomethacin-treated groups. CONCLUSION: In portal hypertensive rats pretreated with NNA and/or indomethacin, acute verapamil administration can not reduce the portal pressure, suggesting that NO and prostaglandin play an important role in the pathogenesis of splanchnic arterial vasodilation in portal hypertension. |
| 关 键 词： | 戊脉安 异搏定 冠状动脉扩张药 一氧化氮合酶 前列腺素 |
| 收稿时间： | 2005-10-07 |
Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: role of prostaglandin |
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| Lay Chii-Shyan,May C-M-Y,Lee Fa-Yauh,Tsai Yang-Te,Lee Shou-Dong,Chien Shu,Sinchon Shlomoh. Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: role of prostaglandin[J]. World journal of gastroenterology : WJG, 2006, 12(15): 2351-2356. DOI: 10.3748/wjg.v12.i15.2351 | |
| Authors: | Lay Chii-Shyan May C-M-Y Lee Fa-Yauh Tsai Yang-Te Lee Shou-Dong Chien Shu Sinchon Shlomoh |
| Affiliation: | 1. Division of Hepatology and Gastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, China 2. Division of Gastroenterology, Department of Internal Medicine,Veterans General Hospital, Taipei, National Yang-Ming University School of Medicine, Taipei, China 3. Institute of Biomedical Sciences, Academia Sinica,Taiwan, China 4. Department of Medicine, Columbia University, New York University Medical Center, New York, USA |
| Abstract: | AIM: To investigate the effects of verapamil on nitric oxide (NO) synthesis in a portal vein-ligated rat model. METHODS: Systemic and splanchnic hemodynamics were measured by radiolabeled microspheres in portal hypertensive rats after acute administration of verapamil (2 mg/kg) on chronic treatment with Nw-nitro-L-arginine (NNA)(80 mg/kg) and/or indomethacin (2 mg/kg) . RESULTS: Verapamil (2 mg/kg) caused a marked fall in both arterial pressure and cardiac output accompanied by an insignificant change in the portal pressure and no change in portal venous inflow. This result suggested that verapamil did not cause a reduction in portal vascular resistance of portal hypertensive rats, which was similar between NW- nitro-L-arginine-treated and indomethacin-treated groups. CONCLUSION: In portal hypertensive rats pretreated with NNA and/or indomethacin, acute verapamil administration can not reduce the portal pressure, suggesting that NO and prostaglandin play an important role in the pathogenesis of splanchnic arterial vasodilation in portal hypertension. |
| Keywords: | Verapamil Nitric oxide synthase Portal hypertension |
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