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Failure of genotoxic carcinogens to produce tumors in human skin xenografts transplanted to SCID mice |
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| Authors: | Urano, Koji Katakai, Yuko Tokuda, Yutaka Ueyama, Yoshito Nomura, Tatsuji Yamamoto, Satoshi |
| Affiliation: | 1Central Institute for Experimental Animals 1430 Nogawa, Miyamae-ku, Kawasaki 216, Japan 2Laboratory No.8, Kanagawa Academy of Science and Technology 3-2-1 Sakado, Takatsu-ku, Kawasaki 213, Japan 3Department of Surgery, School of Medicine, Tokai University Boseidai, Isehara 259-11, Japan 4Department of Pathology, School of Medicine, Tokai University Boseidai, Isehara 259-11, Japan 5Department of Pharmacology, School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan |
| Abstract: | Chemical carcinogenesis of human skin was investigated usinghuman skin xenografts (16 full thickness and 48 split thicknessskin grafts) transplanted to CB-17-scid (SCID) mice. Topicalapplication of a carcinogen, i.e. 7, 12-dimethyl-benz[a]anthracene(DMBA), benzo[a]pyrene, methylchol-anthrene or N-methyl-N'-nitro-N-nitrosoguanidine,to the human skin xenografts once a week for 2530 weeksfailed to produce skin tumors. Both DMBA application plus UV-Birradiation and alternate applications of the above four carcinogensin combination with UV-B irradiation also failed to producetumors. All of these treatments induced skin papillomas in skinsof host SCID mice. DMBA induced skin papillomas in allogenicCD-1 mouse skin grafts transplanted to SCID mice. These resultsindicate that susceptibility of human skin to these carcinogenicstimuli is much lower than that of mouse skin. |
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