| 复方黄连降糖片对2型糖尿病大鼠IRS-1基因表达的影响 |
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| 引用本文： | 宋菊敏,舒适,刘小美,宋丽娜,周金芳. 复方黄连降糖片对2型糖尿病大鼠IRS-1基因表达的影响[J]. 上海中医药大学学报, 2009, 0(4): 71-74 |
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| 作者姓名： | 宋菊敏 舒适 刘小美 宋丽娜 周金芳 |
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| 作者单位： | 上海中医药大学基础医学院; |
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| 基金项目： | 上海市科技发展基金资助项目(064119626) |
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| 摘 要： | 目的：探讨复方黄连降糖片治疗2型糖尿病的可能作用机制。方法：对链脲佐菌素注射加高脂饮食诱导的2型糖尿病模型大鼠，给予复方黄连降糖片治疗8周。氧化酶法测定血糖，放射免疫双抗体法测定血清胰岛素，RT—PCR法测定大鼠肝脏、骨骼肌和脂肪组织IILS-1 mRNA的表达及Western blot法测定肝脏、骨骼肌和脂肪组织IRS-1蛋白的表达。结果：复方黄连降糖片治疗组大鼠的血糖和血清胰岛素均有所下降，各组织IRS-1的基因表达均显著提高。结论：复方黄连降糖片可能通过提高外周组织IRS-1的基因表达，从而对2型糖尿病起到治疗的作用。
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| 关 键 词： | 2型糖尿病 复方黄连降糖片 胰岛素受体底物-1 实验研究 |
Effects of "Compound Huanglian Jiangtang Tablet" on Gene Expression of IRS-1 in Type 2 Diabetes Mellitus Rats |
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| SONG Ju-min SHU Shi LIU Xiao-mei SONG Li-na ZHOU Jin-fangShanghai University of Traditional Chinese Medicine. Effects of "Compound Huanglian Jiangtang Tablet" on Gene Expression of IRS-1 in Type 2 Diabetes Mellitus Rats[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2009, 0(4): 71-74 |
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| Authors: | SONG Ju-min SHU Shi LIU Xiao-mei SONG Li-na ZHOU Jin-fangShanghai University of Traditional Chinese Medicine |
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| Affiliation: | (Shanghai University of Traditional Chinese Medicine) |
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| Abstract: | Objective:To investigate the possible mechanism of "Compound Huanglian Jiangtang Tablet" (CHJT) in treating type 2 diabetes. Methods: The model of type 2 diabetic rats was induced by streptozotocin injection and high-fat diet and administered with CHJT for 8 weeks. Blood glucose was detected by enzymic method,blood insulin was detected by RIA,the expression of IRS-1 mRNA and protein in liver,muscle and fat of type 2 diabetic rats were determined by RT-PCR and western blot analysis. Results: In CHJT group,bo... |
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| Keywords: | Type 2 diabetes ＂Compound Huanglian Jiangtang Tablet＂ （CHJT） insulin receptor substrate-1 （IRS-I） experimental study |
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