A Study of HLA in Japanese Patients with Rheumatic Fever |
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| Authors: | Kenji Naritomi MD Kawano Yoshifumi MD Hiroshi Miyazaki MD Masashi Hokonohara MD Koichiro Miyata MD Tamotu Terawaki MD |
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| Institution: | Department of Pediatrics, Faculty of Medicine, Kagoshima University. |
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| Abstract: | HLA was analysed to study an aspect of genetic background of susceptibility to rheumatic fever. The frequency of HLA was determined in 66 Japanese patients with rheumatic fever and compared with 95 healthy Japanese controls by chi-square method with Yates' correction. The frequency of Bw35 was increased significantly in rheumatic fever group compared with control group (Pc < 0.01). An association between Bw35 and rheumatic fever may imply that rheumatic fever is an autoimmune disease. And the susceptibility to rheumatic fever may be controlled by immune response genes, which have a linkage disequilibrium with Bw35 as an immunogenetic background. |
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| Keywords: | HLA Rheumatic fever Disease susceptibility |
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