| 上海汉族人群MICA基因第5外显子微卫星多态性研究 |
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| 引用本文： | 郭忠慧,许玲娣,范丽安,葛瑜,姚芳娟,杨珏琴. 上海汉族人群MICA基因第5外显子微卫星多态性研究[J]. 中华医学遗传学杂志, 2000, 17(5): 332-335 |
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| 作者姓名： | 郭忠慧 许玲娣 范丽安 葛瑜 姚芳娟 杨珏琴 |
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| 作者单位： | 1. 上海第二医科大学上海市免疫学研究所200025;上海市血液中心
2. 上海第二医科大学上海市免疫学研究所200025 |
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| 基金项目： | 国家自然科学基金(39970742),卫生部科研基金(98-2-308)和上海-联合利华研究基金(9911) |
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| 摘 要： | 目的 了解上海地区汉族人群ＭＩＣＡ基因第５外显子微卫生多态性分布，以及ＭＩＣＡ基因与其紧密连锁的ＨＬＡ－Ｂ基因位点的关系。方法 用ＰＣＲ－异源双链分析法，对１７５名正常无关个体的ＭＩＣＡ基因第５外显子微卫星多态性的分布进行研究。结果 （１）上海地区汉族人群ＭＩＣＡ基因第５外显子存在５种等位基因，其中ＭＩＣＡ＊Ａ５最为常见（３９．１４％），其次为＊Ａ５．１（２２．２９％）；（２）ＭＩＣＡ等位基因与Ｈ
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| 关 键 词： | MICA基因 人类白细胞抗原 微卫星多态性 |
| 修稿时间： | 1999-10-20 |
Study on polymorphism of MICA exon 5 microsatellite in Shanghai Han population |
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| GUO Zhonghui,XU Lingdi,FAN Lian,GE Yu,YAO Fangjuan,YANG Jueqin.. Study on polymorphism of MICA exon 5 microsatellite in Shanghai Han population[J]. Chinese journal of medical genetics, 2000, 17(5): 332-335 |
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| Authors: | GUO Zhonghui XU Lingdi FAN Lian GE Yu YAO Fangjuan YANG Jueqin. |
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| Affiliation: | Shanghai Second Medical University, Shanghai Institute of Immunology, Shanghai, 200025 P.R.China. |
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| Abstract: | Objective To investigate the polymorphism distribution of MICA gene exon 5 microsatellite in Shanghai Han population and study the relationship of MICA gene and its closely linked gene HLA B. Methods The microsatellite polymorphism of MICA exon 5 in 175 unrelated healthy individuals were investigated using PCR heteroduplex analysis. Results (1)There are 5 alleles of the microsatellite polymorphism in exon 5 of the MICA gene in Shanghai Han population, the gene frequency of MICA*A5 is the highest(39.14%), the next is MICA*A5.1(22.29%). (2)There is strong linkage disequilibrium between the HLA B and MICA STR loci, e.g. MICA*A5 and HLA B15, MICA*A4 and HLA B27.Conclusion The polymorphism distribution of MICA gene and the linkage disequilibrium between MICA and HLA B have deviations in different ethnic groups. |
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| Keywords: | MICA gene human leukocyte antigen microsatellite heteroduplex analysis linkage disequilibrium |
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