α-菠菜甾醇的抗炎作用

α-菠菜甾醇对动物角叉菜胶和热烫性足肿胀、巴豆油气囊肿肉芽组织增生均有明显抑制作用,其抗炎作用机理可能抑制PGE₂、缓激肽的合成或释放。明显抑制PGE₂、缓激肽、组胺、5-HT等炎症介质的致炎作用,抑制白细胞游走。并证明其抗炎作用不依赖于肾上腺垂体系统,但对肾上腺皮质功能也有明显的促进作用。

Anti-inflammatory effect of alpha-spinasterol

a-Spinasterol was isolated from Bupleururn chinense DC. The compound was shown to suppress markedly the swelling of the hind paw induced by injection of carrageenin in intact and in adrenalectomized rats and mice. It also showed significant suppressive effects on scald oedema of the hind paw in rats and on proliferation of granulation tissue of croton oil induced air pouch granuloma in rats. Some inhibition of exudation of the granuloma pouch was also observed. In addition, α-spinasterol was found to significantly reduce the fever induced by se injection of 15% yeast suspension 20 ml/kg in rats. The ip LD₅₀ of α-spinasterol in mice was 478.8±9.28 mg/kg.Experimental results indicate that the mechanism of antiinflammatory effects of α-spinasterol is rather complicated. Marked inhibitory effects on synthysis or release of prostaglandin E (PGE) and bradykinin (BK) as well as on phlogistic effect of PGE2, BK, histamine and 5-HT were demonstrated. Inhibition of leucocyte migratory response was also observed. These actions of α-spinasterol seem not to be related to stimulation of the pituitary-adrenal axis. However, the weight of adrenal gland was increased significantly by ip of α-spinasterol 48 mg/kg once daily for 7 successive days.