国产辛伐他汀与舒降之治疗原发性高胆固醇血症的疗效比较

为研究外源必睾酮对雄性高脂血症大鼠早期动脉粥样硬化形成的影响及其作用机制，将雄性Ｗｉｓｔａｒ大鼠随机均分为正常组、高脂组和治疗组（环苡丙酸睾酮，２．５ｍｇ／ｋｇ，肌注），１２周后分别测定血脂、血浆脂质过氧化物及肝脏和主 度含量，光镜检查主动脉内膜形态。结果表明，治疗组与高脂组相比，血浆脂质及脂蛋白水平相差不显著，血浆脂质过氧化物含量升高；治疗组肝脏脂质含量低于高脂组，而主动脉脂质含量高于高脂组，治

Effects of Exogenous Testosterone on Early Atherosclerosis in Male Hypercholesterolemic Rats

Aim To determine the influence of exogenous testosterone on early atherosclerosis in cholesterol-fed male Wistar rats and its possible mechanisms. Methods Thirty-six male Wistar rats were randomly assigned to the three groups: normal group, cholesterol group, treated group (testosterone cypionate,2.5 mg/kg, im.); plasma lipids and the lipids content of aorta and liver were analyzed with enzymatic methods after twelve weeks, aortic intima were examined with light microscope. Results Plasma lipids and lipoproteins were not significantly different between cholesterol group and treated group, the treated rats had significantly higher plasma lipid oxidative peroxidation products value, lower hepatic lipids contents, but higher aortic lipids contents than the cholesterol group, the number of monocytes adhering to endothelial cells and oil red O positive foam cells was more in the treated group than the cholesterol group. Conclusion Exogenous testosterone accelerated early atherosclerosis in male hypercholesterolemic rats.