Glycyrrhizin withdrawal followed by human lymphoblastoid interferon in the treatment of chronic hepatitis B |
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Authors: | Jun Hayashi M.D. Wataru Kajiyama Akinori Noguchi Koya Nakashima Miki Hirata Shin Hayashi Seizaburo Kashiwagi |
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Affiliation: | 1. Department of General Medicine, Kyushu University Hospital, 71 Higashiku, 812, Fukuoka, Japan
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Abstract: | Seventeen patients with chronic hepatitis B were treated with a 4-week administration of glycyrrhizin followed by a 4-week treatment with human lymphoblastoid interferon, then followed for 6 months after the end of treatment. All were positive for hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B virus-associated DNA polymerase (DNA-p) for at least 6 months before entry. All patients were Japanese and none of them were homosexuals. Eleven patients lost DNA-p activity and 10 of them lost HBeAg. Three of these 10 patients had antibody to HBeAg. In 10 patients who became HBeAg-negative, alanine aminotransferase levels after glycyrrhizin administration were higher and initial DNA-p activities relatively lower than the levels found in seven patients who remained HBeAg-positive. The immunomodulater provided by a short course of glycyrrhizin before administration of human lymphoblastoid interferon may be an effective treatment for patients with chronic hepatitis B. |
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Keywords: | chronic hepatitis B glycyrrhizin human lymphoblastoid interferon |
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