Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis |
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| Authors: | Michael Sander Claudia D Spies Viktoria Martiny Christoph Rosenthal Klaus-Dieter Wernecke Christian von Heymann |
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| Affiliation: | 1.Department of Anaesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany;2.SOSTANA (Sophisticated Statistical Analysis) GmbH and Charité-Universitätsmedizin Berlin, Wildensteiner Strasse 27, 10318 Berlin, Germany |
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| Abstract: | Introduction Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding. Because of safety concerns, aprotinin was withdrawn from the market in 2007. Since then, tranexamic acid (TXA) has become the antifibrinolytic treatment of choice in many heart centers. The safety profile of TXA has not been extensively studied. Therefore, the aim of this study was to evaluate safety and efficiency of TXA compared with aprotinin in cardiac surgery. |
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