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Effect of calcium and magnesium on neurotoxicity and blood platinum concentrations in patients receiving mFOLFOX6 therapy: a prospective randomized study |
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| Authors: | Keiichiro Ishibashi Norimichi Okada Tatsuya Miyazaki Motohiko Sano Hideyuki Ishida |
| Institution: | (1) Department of Gastrointestinal and General Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda-Zujidocho, Kawagoe Saitama, 350-8550, Japan;(2) Department of Pharmaceutical Services, Saitama Medical Center, Saitama Medical University, 1981 Kamoda-Zujidocho, Kawagoe Saitama, 350-8550, Japan |
| Abstract: | BackgroundWhether the administration of calcium (Ca) and magnesium (Mg) can reduce oxaliplatin-related neurotoxicity remains controversial. In addition, little is known about the effects of Ca/Mg on the blood level of platinum or objective tumor progression. |
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