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Whole lung lavage: a unique model for ultrasound assessment of lung aeration changes |
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| Authors: | Gabriele Via Daniel Lichtenstein Francesco Mojoli Giuseppe Rodi Luca Neri Enrico Storti Catherine Klersy Giorgio Iotti Antonio Braschi |
| Affiliation: | 1. 1st Department of Anesthesia and Intensive Care, IRCCS Policlinico San Matteo Foundation, University of Pavia, Piazzale Golgi 2, 27100, Pavia, Italy 3. Service de Réanimation Médicale, H?pital Ambroise, Paré, 92100, Boulogne (Paris-Ouest), France 4. General ICU, Azienda Ospedaliera Niguarda Ca’ Granda, 20162, Milan, Italy 2. Service of Biometry and Clinical Epidemiology, Scientific Direction, IRCCS Policlinico San Matteo Foundation, University of Pavia, Piazzale Golgi 2, 27100, Pavia, Italy 5. 2nd Department of Anesthesia and Intensive Care, IRCCS Policlinico San Matteo Foundation, University of Pavia, Piazzale Golgi 2, 27100, Pavia, Italy |
| Abstract: | PurposeWhole lung lavage (WLL) pathophysiologically represents a human model of controlled lung de-aeration, resembling various pathological conditions encountered in the critically ill. Through one-lung ventilation and progressive alveolar flooding, it mimics, respectively, re-absorption atelectasis formation and lung consolidation. With re-ventilation of the treated lung, PEEP application and diuretics administration, it then creates a model of pulmonary edema and its progressive resolution. No studies have so far described lung aeration changes during WLL with ultrasound: objectives of the study were to describe ultrasound findings during WLL with validated semiotics in the critically ill and to investigate their relation with the lung’s state of relative aeration. |
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