| 侧脑室和静脉注射降钙素基因相关肽对大鼠血压和心率的影响 |
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| 引用本文： | 徐东,韩启德,汤健. 侧脑室和静脉注射降钙素基因相关肽对大鼠血压和心率的影响[J]. 北京大学学报(医学版), 1989, 0(2) |
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| 作者姓名： | 徐东 韩启德 汤健 |
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| 作者单位： | 北京医科大学心肺内分泌研究室(徐东)，北京医科大学第三医院内科心血管研究室(韩启德)，北京医科大学心肺内分泌研究室(汤健) |
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| 摘 要： | 本文通过大鼠动物实验,发现静脉和侧脑室注射降钙素基因相关肽对大鼠血压和心率具有不同的作用,并具有剂量效应关系。此外,还对其作用机制进行了初步分析。
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| 关 键 词： | 降钙素基因相关肽 血压 心率 |
EFFECTS OF INTRACEREBROVENTRICULAR OR INTRAVENOUS INJECTION OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) INTO RATS ON MEAN ARTERIAL PRESSURE AND HEART RATE |
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| Laboratory of Cardiopulmonary Endocrinology Xu Dong,et al. EFFECTS OF INTRACEREBROVENTRICULAR OR INTRAVENOUS INJECTION OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) INTO RATS ON MEAN ARTERIAL PRESSURE AND HEART RATE[J]. Journal of Peking University. Health sciences, 1989, 0(2) |
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| Authors: | Laboratory of Cardiopulmonary Endocrinology Xu Dong et al |
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| Abstract: | It was found that effects of intracerebroventricular (icv) or intravenous(iv) injection of calcitonin gene-related peptide on mean arterial pressure(MAP) and heart rate (HR) were different in rat study. Icv injection of CGRP increased MAP and HR, and this effect was blocked by reserpine. Iv injection of CGRP decreased MAP, and this effect could not be blocked by atropine and vagotomy. In addition, CGRP could dilate the rat caudal artery.These data suggest that CGRP has varieties of functions in central nervous system and cardiovascular system. |
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| Keywords: | Calcitonin gene-related peptide Mean arterial pressure Heart rate |
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