Bcl-2在子宫内膜和子宫腺肌症内膜中的表达

采用免疫组织化学ABC法检测凋亡调节蛋白bcl 2在正常子宫内膜和腺肌症正位、异位内膜中的表达。结果显示 :①在正常子宫内膜和腺肌症正位内膜中 ,bcl 2 表达相似 ,主要见于腺上皮细胞 ,并有明显的周期性变化 ;②在子宫腺肌症月经各期的异位内膜中 ,bcl 2持续表达 ,且无周期性变化。提示 :bcl 2主要存在于子宫内膜腺上皮细胞 ,其周期性变化对正常子宫内膜腺上皮细胞增殖和生理性死亡脱落起重要作用 ,从而调节月经 ;bcl 2在子宫腺肌症内膜中持续表达 ,使异位内膜腺上皮细胞得以长期增殖而发病。

Expression of bcl-2 in the normal endometrium and endometrium of adenomyosis

Using immunohistochemical ABC staining, we detected the expression and role of bcl 2 in normal endometrium(n=17) and eutopic and ectopic endometrium with adenomyosis(n=16) during the menstrual cycle. The first result was that the expressions of bcl 2 in the eutopic endometrium were the same as the normal endometrium, showing predominantly in the glandular epithelial cells, and obviously cyclic changes throughtout the menstrual cycle. This result suggests that these changes may be regulated by ovarian hormone and play an important role in the proliferation and physiologic death of normal endometrial glandular epithelial cells to regulate the menstrual cycle. Bcl 2 expression in the glandular cells of ectopic endometrium of adenomyosis had no cyclic change and bcl 2 staining had remained in the whole menstrual cycle. The second result suggests that the above mentioned phenomena may play an important role in the pathogenesis of adenomyosis.