| 宫颈癌中细胞增殖和细胞凋亡的关系研究 |
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| 引用本文： | 薛月珍,丰有吉,朱关珍.宫颈癌中细胞增殖和细胞凋亡的关系研究[J].中德临床肿瘤学杂志,2002,1(2):102-103. |
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| 作者姓名： | 薛月珍 丰有吉 朱关珍 |
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| 作者单位： | 上海市第六人民医院妇产科 200233
(薛月珍，丰有吉，朱关珍)，上海市第六人民医院妇产科 200233(张惜阴) |
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| 摘 要： | Objective To study the relationship between cell proliferation and apoptosis in cervical carcinoma and its clinical significance.Methods The cell proliferation and apoptosis of cervical epithelial cells in archival formalin-fixed,paraffin-embedded tissue sections of normal cervix ,cervical intraepithelial neoplasms(CN) and cervical squamous carcinoma were tested by using immunohistochemistry assay and DNA nick end-labeling technigue.The proliferation index(PI) and apoptosis index(AI) were calculated and their correlation with clinical and pathological data was analyzed. Results PI was gradually increased,but the AI and AI/PI ratio decreased from normal cervical epithelium,CIN to cervical carcinoma. There was no significant relationship among cell proliferation,apoptosis,clinical stages and pathological grades.High AI was always asso-ciated with a poor prognosis of the patients. Conclusion Cell proliferation and apoptosis allow to distinguish among normal epithelium,CIN and cervical carcinoma and are useful for the assessment of the malignant potential of tumor tissues.
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| 关 键 词： | 宫颈癌 细胞增殖 细胞凋亡 关系 鳞癌 上皮癌 |
| 收稿时间： | 22 January 2002 |
Relationship between cell proliferation and apoptosis in cervical carcinoma |
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| Yuezhen Xue,Youji Feng,Guanzhen Zhu,Xiying Zhang.Relationship between cell proliferation and apoptosis in cervical carcinoma[J].The Chinese-German Journal of Clinical Oncology,2002,1(2):102-103. |
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| Authors: | Yuezhen Xue Youji Feng Guanzhen Zhu Xiying Zhang |
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| Institution: | (1) Department of Obstetrics and Gynecology, Shanghai Sixth People's Hospital, 200233 Shanghai, China;(2) Obstetrics and Gynecology Hospital, Shanghai Medical University, 200011 Shanghai, China |
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| Abstract: | Objective To study the relationship between cell proliferation and apoptosis in cervical carcinoma and its clinical significance. Methods The cell proliferation and apoptosis of cervical epithelial cells in archival formalin-fixed, paraffin-embedded tissue sections of normal cervix, cervical intraepithelial neoplasms (GIN) and cervical squamous carcinoma were tested by using immunohistochemistry assay and DNA nick end-labeling technigue. The proliferation index (PI) and apoptosis index (AI) were calculated and their correlation with clinical and pathological data was analyzed.
Results PI was gradually increased, but the AI and AI/PI ratio decreased from normal cervical epithelium, GIN to cervical carcinoma. There was no significant relationship among cell proliferation, apoptosis, clinical stages and pathological grades. High AI was always associated with a poor prognosis of the patients.
Conclusion Cell proliferation and apoptosis allow to distinguish among normal epithelium, GIN and cervical carcinoma and are useful for the assessment of the malignant potential of tumor tissues. |
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| Keywords: | cervical intraepithelial neoplasms cervical squamous carcinoma cell proliferation apoptosis |
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