| 首发精神分裂症和首发抑郁症患者细胞因子的变化及意义 |
| |
| 引用本文： | 师天元,郭新胜,张红亚,李恒芬.首发精神分裂症和首发抑郁症患者细胞因子的变化及意义[J].免疫学杂志,2009,25(4). |
| |
| 作者姓名： | 师天元 郭新胜 张红亚 李恒芬 |
| |
| 作者单位： | 新乡医学院第二附属医院中心实验室 |
| |
| 摘 要： | 目的 探讨首发精神分裂症和首发抑郁症患者病理过程中细胞因子的变化及意义.方法 使用ELISA法对首发精神分裂症和首发抑郁症患者各30例同时测定治疗前后血浆白细胞介素-2、-6(IL-2、-6)和可溶性白细胞介素-2、-6受体(sIL-2R、-6R)浓度,以30名健康人为对照组.结果 治疗前2个患者组血浆IL-2、-6和sIL-2R、-6R均高于对照组(P<0.05或P<0.01);精神分裂症组血浆sIL-2R高于抑郁症组(P<0.05),而IL-2、-6和SIL-6R低于抑郁症组(P<0.01).治疗后,精神分裂症组m浆IL-2和sIL-6R、抑郁症组血浆IL-2、sIL-6R、sIL-2R和IL-6均下降(P<0.01);精神分裂症组血浆IL-2和sIL-6R仍低于抑郁症组(P<0.05);精神分裂症组血浆sIL-2R和IL-6、抑郁症组血浆sIL-6R仍高于对照组(P<0.05或P<0.01).结论 首发精神分裂症和首发抑郁症患者均处于免疫激活状态,细胞因子表达水平的差异可能是二者表现不同临床症状的免疫学基础.
|
| 关 键 词： | 精神分裂症 抑郁症 白细胞介素 可溶性白细胞介素受体 |
Variation of cytokines in first-episode schizophrenia and first-episode depressive disorder patients and its significance |
| |
| SHI Tianyuan,GUO Xinsheng,ZHANG Hongya,LI Hengfen Second Affiliated Hospital,Xinxiang Medical Universiity,Xinxiang ,China.Variation of cytokines in first-episode schizophrenia and first-episode depressive disorder patients and its significance[J].Immunological Journal,2009,25(4). |
| |
| Authors: | SHI Tianyuan GUO Xinsheng ZHANG Hongya LI Hengfen Second Affiliated Hospital Xinxiang Medical Universiity Xinxiang China |
| |
| Institution: | SHI Tianyuan,GUO Xinsheng,ZHANG Hongya,LI Hengfen Second Affiliated Hospital,Xinxiang Medical Universiity,Xinxiang 453002,China |
| |
| Abstract: | Objective To investigate the pathological variation of cytokines in the course of first-episode schizophrenia(sch) and first-episode depressive disorder and its significance.Methods Enzyme-labeled immunosorbent assay(ELISA) was used to measure the levels of IL-2,sIL2R,IL-6,and sIL-6R in plasma of the same batches from both 30 cases of first-episode schizophrenia patient and 30 cases of first-episode depressive disorder patient before and after treatment,while 30 health people were used as normal control.Res... |
| |
| Keywords: | schizophrenia depression interleukin solubility interleukin receptor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
