参麦注射液改善疲劳膈肌舒缩功能的实验研究

目的：观察参麦注射液与氨茶碱对离体大鼠膈肌条疲劳的发生和（或）异性过程的影响之异同性。方法：设立参麦注射液组、氨茶碱组、参麦注射液和氨茶碱合用组（合用药组）及对照组，采用电刺激法，测定等长收缩膈肌条在疲劳和恢复过程中有关指标的变化。结果：膈肌疲劳发生时，其最大舒张速率（ｄＲ／ｄｔｍａｘ）的降低较最大收缩峰值（Ｐｔ）及最大收缩速率（ｄＴ／ｄｔｍａｘ）为早，ｄＴ／ｄｔｍａｘ恢复较晚且不充分。参麦注射液

Experimental Study on Effect of Shenmai Injection in Improving Contractility of Fatigue Diaphragm in Rats

OBJECTIVE: To study and compare the effects of Shenmai Injection (SMI) and aminophylline on pathogenesis and developing process of diaphragmatic fatigue. METHODS: SMI group, aminophylline group, SMI plus aminophylline group and control group of isolated rat's diaphragmatic muscular strip of equal length were set up, and electric stimulation was applied. Changes of related parameters in the fatigue inducing and recovery process were estimated. RESULTS: During fatigue inducing process, the lowering on maximal rates of relaxation (dR/dtmax) was earlier than that on maximal contraction peak (Pt) and contraction rate (dT/dtmax), and restoring of these parameters were restored later and incompletely. SMI could prolong the time Pt needed for reducing 50%, speed up the restoration of Pt. Although aminophylline could increase Pt, it shortened the fatigue inducing time and postponed the recovery. CONCLUSION: Disturbance in the function of relaxation plays important role in diaphragm fatigue induction. Through strengthening the capability to relax, SMI could improve the function of fatigue diaphragm. Aminophylline would damage the relaxation function together with the increasing contraction of diaphragm simultaneously, and this side-effect could be antagonised partly by SMI.