替米沙坦与硝苯地平对原发性高血压伴代谢综合征老年患者大动脉弹性功能的影响

目的:探讨替米沙坦与硝苯地平对原发性高血压伴代谢综合征(metabolic syndrome,MS)的老年患者大动脉弹性功能的影响。方法:选择80例轻中度高血压患者,随机分配至替米沙坦组和硝苯地平组,每组40例。用药6个月,比较治疗前、后两组患者的颈-股动脉脉搏波速度(C-F PWV)的变化。结果:治疗后两组患者的血压明显降低(P<0.01),治疗前、后组间比较收缩压及舒张压,差异均无统计学意义(P>0.05)。两组的C-F PWV较治疗前均有显著降低(P<0.05),替米沙坦组降低更加明显(P<0.05)。结论:替米沙坦与硝苯地平控释片均可以改善高血压伴MS的老年患者的大动脉弹性,替米沙坦的作用优于硝苯地平。

The effect of telmisartan and nifedipine on aortic stiffness in old patients with hypertension and metabolic syndrome

Objective：To explore the effect of telmisartan and nifedipine on aortic stiffness in old pa- tients with hypertension and metabolic syndrome（MS）. Methods：40 patients with hypertension and MS orally received telmisartan and 40 patients orally received nifedipine controlled release pellets for 6 months. The level of carotid femoral pulse wave velocity（ C-F PWV）were observed. Results：the level of blood pressure decrease obviously on both groups （ P 〈 0.05 ）. The level of C-F PWV was significantly decrease after telmisartan and nifedipine （P 〈 0.05）. The lower PWV with telmisartan indicates a lower aortic stiffness （P 〈 0. 05 ）. Conclu- sion：Both telmisartan and nifedipine can improve aortic stiffness in old patients with hypertension and MS, we proved a more significant effect of telmisartan compared to nifedipine.