慢性乙型肝炎患者HBVDNA载量与肝组织炎症及纤维化程度的相关性分析

目的研究慢性乙型肝炎(CHB)患者血清HBV DNA载量与肝组织炎症及纤维化程度间的相关性。方法将169例CHB患者根据血清HBeAg分为HBeAg阳性组(110例)和HBeAg阴性组(59例),回顾性分析血清HBV DNA载量与肝组织病理炎症分级、纤维化分期之间关系。结果 HBeAg阳性组与HBeAg阴性组血清HBV DNA载量分别为(6.9±1.3)log10拷贝/ml和(4.7±1.8)log10拷贝/ml,两组比较差异有统计学意义(P=0.024)。HBeAg阳性组患者肝组织炎症活动度G1组为9例、G2组为80例、G3~4组为21例,其血清HBV DNA载量分别为(5.7±1.4)log10拷贝/ml、(6.4±1.8)log10拷贝/ml、(7.2±1.1)log10拷贝/ml,3组患者血清HBV DNA载量比较,差异无统计学意义(P=0.069)。肝组织纤维化程度S1组为28例、S2组为50例、S3~4组为32例,其血清HBV DNA载量分别为(6.9±1.1)log10拷贝/ml、(6.9±1.4)log10拷贝/ml、(6.8±4.2)log10拷贝/ml,3组患者血清HBV DNA载量比较,差异无统计学意义(P=0.079)。HBeAg阴性组患者肝组织炎症活动度G1组为6例、G2组为19例、G3~4组为34例,其血清HBV DNA载量分别为(2.2±1.9)log10拷贝/ml、(4.9±1.5)log10拷贝/ml、(5.4±1.8)log10拷贝/ml,3组患者血清HBV DNA载量比较,差异有统计学意义(P=0.014);肝组织纤维化程度S1组为12例、S2组为30例、S3~4组为17例,其血清HBV DNA载量分别为(2.6±4.1)log10拷贝/ml、(5.3±1.3)log10拷贝/ml、(5.6±1.7)log10拷贝/ml,3组血清HBV DNA载量比较,差异有统计学意义(P=0.026)。结论 HBeAg阳性CHB患者血清HBV DNA载量与肝组织炎症及纤维化程度无显著相关。HBeAg阴性CHB患者血清HBV DNA载量较高者,其肝组织炎症及纤维化程度较高。

Analysis on correlationship between serum HBV DNA level and liver inlfammation and ifbrosis degrees in patients with chronic hepatitis B

Objective To investigate the correlation between serum HBV DNA level and liver tissue inlfammation and ifbrosis degrees in the patients with chronic hepatitis B （CHB）. Methods The relationship between HBV DNA loads, liver histological inlfammation grades and ifbrosis stages of 169 cases was analyzed. Results The serum HBV DNA loads in HBeAg-positive group with inlfammation grade G1 group （9 cases）, G2 group （80 cases） and G3~4 group （21 cases） were （5.7 ± 1.4） log10 copies/ml, （6.4 ± 1.8） log10 copies/ml and （7.2 ± 1.1） log10 copies/ml, respectively. There was no signiifcant differences among patients of three inlfammation grades （P=0.069）. The serum HBV DNA loads in HBeAg-positive group with liver tissues ifbrosis stages of S1 group （28 cases）, S2 group （50 cases）, S3~4 group （32 cases） were （6.9 ± 1.1） log10 copies/ml, （6.8 ± 4.2） log10 copies/ml, （6.9 ± 1.4） log10 copies/ml, respectively, with no signiifcant differences （P=0.079）. The serum HBV DNA loads in HBeAg-negative group with inlfammation grades G1 group （6 cases）, G2 group （19 Objective To investigate the correlation between serum HBV DNA level and liver tissue inlfammation and ifbrosis degrees in the patients with chronic hepatitis B （CHB）. Methods The relationship between HBV DNA loads, liver histological inlfammation grades and ifbrosis stages of 169 cases was analyzed. Results The serum HBV DNA loads in HBeAg-positive group with inlfammation grade G1 group （9 cases）, G2 group （80 cases） and G3~4 group （21 cases） were （5.7 ± 1.4） log10 copies/ml, （6.4 ± 1.8） log10 copies/ml and （7.2 ± 1.1） log10 copies/ml, respectively. There was no signiifcant differences among patients of three inlfammation grades （P=0.069）. The serum HBV DNA loads in HBeAg-positive group with liver tissues ifbrosis stages of S1 group （28 cases）, S2 group （50 cases）, S3~4 group （32 cases） were （6.9 ± 1.1） log10 copies/ml, （6.8 ± 4.2） log10 copies/ml, （6.9 ± 1.4） log10 copies/ml, respectively, with no signiifcant differences （P=0.079）. The serum HBV DNA loads in HBeAg-negative group with inlfammation grades G1 group （6 cases）, G2 group （19 cases） and G3~4 group （34 cases） were （2.2 ± 1.9） log10 copies/ml, （4.9 ± 1.5） log10 copies/ml, （5.4 ± 1.8） log10 copies/ml, respectively. There was signiifcant differences among the three groups （P=0.014）. The serum HBV DNA loads in HBeAg-negative group with liver tissues ifbrosis stages of S1 group （12 cases）, S2 group （30 cases）, S3~4 group （17 cases） were （2.6 ± 4.1） log10 copies/ml, （5.3 ± 1.3） log10 copies/ml, （5.6 ± 1.7） log10 copies/ml, respectively, with no signiifcant difference （P=0.026）. Conclusions The serum HBV DNA level was not signiifcantly correlated with the inlfammation grades and ifbrosis stages of liver tissues in HBeAg-positive patients which display a positive correlation in HBeAg-negative patients.