| 诱生型一氧化氮合酶在顺铂所致豚鼠耳蜗损伤中的表达 |
| |
| 引用本文： | 熊敏,汪建,何青莲,邓恒山,尤景敏.诱生型一氧化氮合酶在顺铂所致豚鼠耳蜗损伤中的表达[J].听力学及言语疾病杂志,2002,10(4):260-261,I002. |
| |
| 作者姓名： | 熊敏 汪建 何青莲 邓恒山 尤景敏 |
| |
| 作者单位： | 1. 广州军区广州总医院耳鼻咽喉科,广州,510010
2. 广州中医药大学第二临床学院病,理科 |
| |
| 摘 要： | 目的：检测诱生型一氧化氮合酶（iNOS）在顺铂所致豚鼠耳蜗损伤中的表达。方法：实验组豚鼠腹腔注射顺铂造成耳蜗损伤，对照组豚鼠腹腔注射等量生理盐水。用免疫组织化学的方法检测iNOS在耳蜗中的表达。结果：iNOS在实验组耳蜗的表达呈阳性，在对照组耳蜗的表达呈阴性。结论：iNOS在顺铂损伤耳蜗中呈阳性表达，iNOS催化产生大量NO而致耳蜗损伤。
|
| 关 键 词： | 耳蜗损伤 顺铂 一氧化氮合酶 免疫组织化学 耳毒性 |
| 文章编号： | 1006-7299(2002)04-0260-02 |
Expression of Inducible Nitric Oxide Synthase in the Cochlea of Guinea Pig Damaged by Cisplatin |
| |
| Xiong Min,Wang Jian,He Qinglian,et al..Expression of Inducible Nitric Oxide Synthase in the Cochlea of Guinea Pig Damaged by Cisplatin[J].Journal of Audiology and Speech Pathology,2002,10(4):260-261,I002. |
| |
| Authors: | Xiong Min Wang Jian He Qinglian |
| |
| Abstract: | Objective To detect the expression of inducible nitric oxide synthase (iNOS) in the cochlea of guinea pigs damaged by cisplatin.Methods The guinea pigs of experimental group were treated with injection of gentamicin intraperitoneally, and the guinea pigs of the control group were treated with the same dose of saline. The method of immunohistochemistry was used to detect iNOS in the cochlea for both groups.Results The expression of iNOS was positive in the cochlea of guinea pigs of experimental group. and negative in that of control group.Conclusion The expression of iNOS was positive in the cochlea damaged by cisplatin. It suggests that nitric oxide (NO) takes a very important part in the process of cochlea injury with cisplatin. |
| |
| Keywords: | Cisplatin Cochlea Nitric oxide synthase Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
