Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers |
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| Authors: | Sevillano David Giménez María-José Cercenado Emilia Cafini Fabio Gené Amadeo Alou Luis Marco Francesc Martínez-Martínez Luis Coronel Pilar Aguilar Lorenzo |
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| Affiliation: | David Sevillano, María-José Giménez, Emilia Cercenado, Fabio Cafini, Amadeo Gené, Luis Alou, Francesc Marco, Luis Martínez-Martínez, Pilar Coronel, and Lorenzo Aguilar |
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| Abstract: | Among 165 Spanish Haemophilus influenzae isolates with mutations in the ftsI gene (ftsI+) (2005 to 2007), 73% were β-lactamase negative and 26.7% were positive. The proportion of β-lactamase-negative isolates to β-lactamase-positive isolates was 2:1 to 4:1 in general, versus 1:3 in pediatric hospitals. Among 44 β-lactamase-positive strains, 8 strains produced ROB-1 (5 from the pediatric hospital). β-Lactamase-positive ftsI+ strains were phylogenetically closer than were β-lactamase-negative strains. |
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