昆明山海棠治疗无菌性脓疱性皮肤病35例疗效观察

目的 观察昆明山海棠治疗无菌性脓疱性皮肤病的疗效及作用机制。方法 昆明山海棠30－50g/d分3次剪服共4周，并用该药液浸泡患处，治疗无菌性脓疱性皮肤病患者35例，同时用放免疫法检测8例患者血浆TXB2和6－keto-PGF1α水平。结果 治愈率为60％，总有效率为97．4％，治疗前后血浆TXB2和6－keto-PGF1α含量有显著差异（P＜0．01）。结论 昆明山海棠是治疗无菌性脓疱性皮肤病的一种有效药物，其抗炎机制部分是通过降低TXB2和6－keto-PGF1a水平来实现的。

Observation of Curative Effect of Tripterygium Hypoglaucum on Treating 35 Cases of Non-Bacterial pustula Dermatoses

Objective To observe the curutive effect and mechanism of Tripterygium Hypoglaucum on treating non bacterial pustular dermatoses.Methods 35 cases were treated with Tripterygium Hypoglaucum decoction 30-50g/daily,3 times a day for 4 weeks,soaking affected part with the decoction,detecting the levels of serum TXB 2 and 6 keto PGF 1a in 8 cases of patients.Results The cure rate was 60%,and the total effective rate was 97.4%,there was a significant difference of levels of TXB 2 and 6 keto PGF 1a in patient's sera before and after treatment( P <0.01).Conclusion Tripterygium hypoglaucum is an effective medicine to treat non bacterial pustular dermatoses,part of anti inflammatcry mechanism depends on reducing the levels of TXB 2 and 6 keto PGF 1a .