| 非小细胞肺癌CD44v6表达的免疫组化研究 |
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| 引用本文： | 褚晓源,陈龙邦,王靖华.非小细胞肺癌CD44v6表达的免疫组化研究[J].肿瘤,2000,20(1):63-65. |
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| 作者姓名： | 褚晓源 陈龙邦 王靖华 |
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| 作者单位： | 褚晓源（南京军区南京总医院肿瘤内科，南京市，210002）;陈龙邦（南京军区南京总医院肿瘤内科，南京市，210002）;王靖华（南京军区南京总医院肿瘤内科，南京市，210002）;龚涌灵（南京军区南京总医院肿瘤内科，南京市，210002） |
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| 摘 要： | 目的 研究ＣＤ４４v６在非小细胞肺癌的表达及其临床意义。方法 应用链霉菌抗生物素 蛋白－过氧化物酶（ＳＰ）法染色测定６４例非小细胞肺癌细胞标本ＣＤ４４v６的表达水 平，并分析其与病理类型、淋巴结转移、肿瘤大小及临床分期之间的关系。结果 ＣＤ４４v６在非小细胞肺癌组织中表达的阳性率为６６．２％，显著高于癌旁正常组织（７．７％ ），且ＣＤ４４v６的表达与淋巴结转移及临床分期有关（Ｐ＜０．０５），但与病理类型
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| 关 键 词： | 肺肿瘤 非小细胞肺癌 CD44v6 免疫组织化学 |
| 文章编号： | 1000-7431(2000)01-0063-03 |
| 修稿时间： | 1999-07-12 |
STUDY ON EXPRESSION OF
CD44v6 IN
HUMAN NON-SMALL CELL LUNG CANCER |
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| CHU Xiao yuan,CHEN Long bang,WANG Jing hua et al.STUDY ON EXPRESSION OF
CD44v6 IN
HUMAN NON-SMALL CELL LUNG CANCER[J].Tumor,2000,20(1):63-65. |
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| Authors: | CHU Xiao yuan CHEN Long bang WANG Jing hua |
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| Institution: | CHU Xiao yuan,CHEN Long bang,WANG Jing hua et al.Department of Oncology,Nanjing General Hospital of PLA |
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| Abstract: | Objective To study the clinical significance of expression of CD44v6 in non small cell lung cancer (NSCLC). Methods By using SP immunohistochemical method with anti CD44v6 monoclonal antibody, the expression of CD44v6 in 65 cases NSCLC and its correlations with pathological types, metastatic states of lymph nodes, size of tumor mass and clinical stages were studied. Results The total positive rate (66 2 %) of CD44v6 expression in NSCLC was much higher than that in adjacent normal tissues (7 7 %), and it also correlated with the stages of lymph nodes involved and the clinical staging ( P <0 05), but had no correlation with pathological types. Conclusion The data demonstrated that expression of CD44v6 might be used as an objective indicator for the metastatic potency. extent of invation and the prognosis in NSCLC. |
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| Keywords: | Carcinoma non small cell lung Immunohistochemistry Cell adhesion molecules |
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