Multitasking of interferon regulatory factor-4 in early B cells |
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Authors: | Nielsen Peter Grosschedl Rudolf |
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Affiliation: | Max Planck Institute of Immunobiology, Freiburg, Germany. |
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Abstract: | Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling. |
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