医用聚氨酯生物相容性研究新进展

聚氨酯因有良好的生物相容性和机械性能，而被广泛用于生物医学领域，但聚氨酯长期植入人体内，也会引起机体的炎症反应，使材料发生老化降解现象。因而要进一步提高医用聚氨酯的生物相容性，使其与机体生理环境更加相容，不诱发或少诱发炎症反应，就要使材料表面更加生物化，可以维持蛋白的正常构象。本文综述了以仿生化为基础提高医用聚氨酯生物相容性的两种主要途径－表面内皮细胞化及仿生物膜结构（表面膦脂化），并总结了其实施方法及存在的问题。

The Advance of Research for Biocompatibility of Medical Polyurethanes

Polyurethanes are popularly used in cardiovascular and other biomedical fields due to their good biocompatibility as well as mechanical properties. But they are subject to biodegradation in vivo for a long time, and cause inflammation, so improving the biocompatibility of medical polyurethanes is an important subject of biomaterials. Recent researches have focused on biological modelling of biomaterials for improving the biocompatibility of polyurethanes. This paper reviews two main methods for improving biocompatibility of polyurethanes endothelial cells seeding and mimic biomembrane (phospholipid surface), and summarizes the main procedures and questions of these two methods.