癫(癎)术后抗癫(癎)药物的治疗模式

目的 探讨癫(癎)术后抗癫(癎)药物的应用方法及影响因素.方法 2002-2005年在我院接受了手术治疗的170例癫(癎)患者,根据不同手术时段分为3组,A组:2002年至2003年10月的病例;B组:2003年11月至2004年10月药师与临床医生一起对癫(癎)手术患者进行用药教育的病例;C组:2004年11月至2005年10月接受全程化药学服务的病例.对随访1年后各组之间的疗效、用药安全性、抗癫(癎)药应用依从性等指标进行了比较,初步探讨术后应用抗癫(癎)药的规律.结果 B组和C组在疗效(71%、81%)、用药安全性、抗癫(癎)药用药依从性等指标上均优于A组(46%),差异均有统计学意义(X2=7.08、15.50,P<0.05).结论 神经内外科医生、药师合作的个体化癫(癎)术后全程化服务是一种较新的、有效的癫(癎)术后管理模式.

Study on management mode of antiepileptic drugs following epilepsy surgery

Objective To investigate antiepileptic drug application and the influential factors in patients after epilepsy surgery.Methods During the period from 2002 through 2005,170 patients with intractable epilepsy who received epilepsy surgery in Xuanwu hospital were studied.They were divided into 3 groups according to the stages of operation.Patients in group A received epilepsy surgery during 2002 to October 2003,those in group B received initial phannacentieal care after epilepsy surgery during November 2003 to October 2004,and those in group C received integrated pharmaceutical care after epilepsy surgery during November 2004 to October 2005.The clinical outcomes,factors affecting antiepileptic drugs,safety and compliance with antiepileptic medication were analyzed.Results Patient's clinical outcomes(group B was 71%and group C was 81%),safety and compliance with antiepileptic medication in group B and group C are better than those in group A(46%)with a significance difference(X2=7.08,15.50,P<0.05).Conclusions The integrated pharmaceutical care rendered from the cooperation of neurosurgeon,neurologist and clinical pharmaceutist is a new and effective management mode for postsurgical epilepsy patients.