抗生素相关性腹泻的临床分析及治疗

目的:分析抗生素相关性腹泻(AAD)的发病特点,为临床制定有效的预防措施提供依据。方法:回顾性分析我院2006～2008年内科住院接受抗生素治疗的488份病历,对其中42份AAD的临床表现、抗生素使用情况以及治疗和转归等进行统计分析。结果:AAD的发病率为8.6%。应用抗生素时间超过7d、应用广谱抗生素、联合应用2种以上抗生素、年龄大于70岁等患AAD的发病率高于对照组(P<0.05)。结论:合理应用抗生素是预防AAD的关键。

Clinical Analysis and Treatment for Antibiotic Associated Diarrhea

OBJECTIVE： To observe the clinical character of antibiotic associated diarrhea（AAD）in order to provide reference for prevention measures. METHODS： Retrospective analysis was applied to analyze 488 inpatients treated with antibiotics in our hospital from 2006 to 2008, of which 42 AAD cases were analyzed in terms of clinical manifestation,utilization of antibiotics, therapy and prognosis, etc. RESULTS： The incidence of AAD arrived at 8.6%. The reason that incidence of AAD was higher than that of control group was above 7 days of antibiotics treatment, broad-spectrum antibiotic, more than two kinds of antibiotics and over 70 years old. CONCLUSION ： The key point of preventing AAD is rational use of antibiotics.