正交试验优选补气通脉胶囊制备工艺

目的:优选补气通脉胶囊的制备工艺。方法:以大鼠血液流变学指标考察醇沉条件。以药材的浸泡时间、提取次数、加水量、煎煮时间为考察因素,以黄芪甲苷含量为考察指标优选黄芪最佳提取工艺。以丹参素含量为考察指标优选丹参、川芎、枳壳、红花最佳提取工艺。结果:药材最佳提取方法为采用水提取70%醇沉。黄芪最佳提取工艺为浸泡30 min,煎煮2次,每次90 min,按1∶10加水。丹参、川芎、枳壳、红花最佳提取工艺为煎煮90 min,共煎煮2次,按1∶8加水。结论:该生产工艺方法可行、稳定,符合临床需要。

Optimization of the Preparation Technology of Buqi Tongmai Capsule by Orthogonal Experiment

OBJECTIVE： To optimize the preparation technology of Buqi tongmai capsule. METHODS： Orthogonal experiment of exeracting Radix Astragali was conducted with crude drugs soaking time, extracting times, amount of water added and decocting duration as factors and the content of astragaloside as index. Orthogonal experiment of exeracting Salvia miltiorrhiza, Ligusticum chuanxiong, Fructus Aurantii lmmaturus, Carthamus tinctorius was conducted with crude drugs soaking time, amount of water added and decocting duration as factors and the content of tanshinol as index.RESULTS： Water was adopted for extraction and the concentration of alcohol for precipitate was 70 percent. The optimal technology of exeracting Radix Astragali was to soak the crude drugs for 30 min, decoct for 90 min in 10 times of water for 2 times. The optimal technology of exeracting S. miltiorrhiza, L. ckuanxiong, Fructus Aurantii Immaturus, C. tinctorius was to decoct the crude drugs for 90 min, 8 times of water for 2 times. CONCLUSION ： The preparation processes is feasible, stable and meet the demands in the clinic.