超声电导活性骨提取物治疗胫骨骨折的临床观察

目的评估超声电导活性骨提取物治疗高能量胫骨骨折的临床疗效。方法将2007年1月至2012年3月60例采用切开复位内固定或使用带锁髓内钉内固定的胫骨骨折患者完全随机分为试验组和对照组，各30例。试验组采用超声电导活性骨提取物治疗：术后第7天起，每天治疗30min，持续15d，对照组术后予以不含活性骨提取物的超声电导治疗。观察2组治疗效果。结果术后随访5～14个月。试验组胫骨骨折愈合时间为9—15周，平均（11±3）周，无延迟愈合和骨不连发生；对照组为13～36周，平均（18±4）周，延迟愈合3例（愈合时间为8～9个月）。按Johner—Wruhs标准评估，术后12和26周，试验组优良率分别为93．3％（28／30）和100．0％（30／30），对照组为50．0％（15／30）和86．7％（26／30），2组间差异有统计学意义（P〈0．01）。结论超声电导活性骨提取物是一种促进骨折愈合的有效方法。

Clinical observation of bone bioactive extract by electrophonophoresis in treatment of tibial fracture

Objective To evaluate the clinical effect of bone bioactive extract by electrophonophoresis in treatment of tibial fracture. Methods From Jan. 2007 to Mar. 2012, sixty patients with tibial fracture were randomly assigned to the experimental group with bone bioaetive extract of transported by electrophanophoresis （ n = 30 ）or the control group （n=30 ） , whom had been immobilized by either internal or external fixations, were followed up. Patients in the experimental group were provided with bone bioactive extract by electrophonophoresis, 30 min/ day for 15 days from the seventh days postoperation. Control group were not given special treatment. Results The cases were followed up from 5 months to 14 months, with an average of 10 months. The mean time to fracture healing was 11 weeks（9-15 weeks）in the experimental group and was 18 weeks（ 13-36 weeks） in the control group. In the experimental group, no delayed union or nonunion, while 3 cases （ 10% ） delayed union healed from 8 and 9 months in the control group. According to the criteria of Johner-Wruhs, by week 12 and 26 postoperation, there were rate 93.3% and 100.0% in the experimental group, 50.0% and 86.7% in the control group respectively, there was significant difference between the two groups （ P 〈 0. 01 ）. Conclusion Bone bioactive extract of transdermal transport by electrophonophoresis is an effective method treating tibial fracture.