甲硝唑片3种给药方式治疗滴虫性阴道炎的疗效比较

目的:探讨甲硝唑片3种给药方式联合阴道局部用药治疗滴虫性阴道炎的临床疗效。方法:选择我院滴虫性阴道炎患者195例,随机分为3组,在阴道局部用药同时分别予以不同剂量甲硝唑片单次顿服或多次口服,并进行疗效比较。结果:甲硝唑片大剂量单次顿服组治疗后第1、2天的症状缓解率、治愈率、总有效率均高于小剂量多次口服组,差异有显著性(P<0.05);甲硝唑1.6g单次顿服与2.0g单次顿服组间疗效无显著性差异(P>0.05)。结论:甲硝唑片大剂量单次顿服疗效高于小剂量多次口服,1.6g单次顿服与2.0g单次顿服疗效相当。

Clinical Observation of 3 Metronidazol Therapeutic Regimens for Trichomonas Vaginitis

OBJECTIVE： To investigate observation of three metronidazol combined with drug for vaginal local application on trichomnas vaginitis. METHODS： 195 patients with trichomonas vaginitis were randomly divided into three groups. They were treated with drug for vaginal local application plus single dose or multiple dose of metronidazol （p.o）, respectively. Then their curative effects were compared. RESULTS： In single large dose of metronidazol group remission rate, cure rate and total effective rate were higher than in multiple low dose group in the first and the second day. Significant difference was noted between the two groups （P〈0.05）. There was no significant difference between the single dose of metronidazol （1.6 g） and the single dose of metronidazol （2.0 g） （P〉0.05）. CONCLUSION： The curative effect of single large dose of metronidazol was better than the multiple low dose. The therapeutic effect of single dose of metronidazol （1.6 g） is similar to single dose （2.0 g）.