复方阿嗪米特联合马来酸曲美布汀治疗老年人功能性消化不良的疗效观察

目的:观察复方阿嗪米特联合应用马来酸曲美布汀治疗老年人功能性消化不良的疗效及安全性。方法:符合功能性消化不良罗马Ⅲ标准的老年患者48例,随机分为2组:治疗组23例,每次餐前15min口服马来酸曲美布汀200mg,tid,餐后口服复方阿嗪米特2粒,tid,疗程4周;对照组25例,每次单独口服马来酸曲美布汀200mg,tid,疗程4周。治疗前及治疗4周后通过症状问卷的方法评估各消化不良症状的积分及药物副作用。结果:2组患者在年龄、性别、病程和消化不良症状上积分均有较好的匹配性,且均完成了规定的疗程。2组均未出现严重不良反应。与对照组比较,治疗组治疗4周后除上腹痛和上腹烧灼感外,食欲不振、餐后饱胀、早饱感、嗳气等症状积分均显著低于对照组(P<0.05),有效率高于对照组(P<0.05)。结论:与单独服用马来酸曲美布汀比较,复方阿嗪米特联合马来酸曲美布汀对改善老年人功能性消化不良症状有明显疗效,且未见严重不良反应。

Efficacy Observation of Compound Azintamide and Trimebutine Maleate in the Treatment of Functional Dyspepsia in Elderly Patients

OBJECTIVE： To assess the efficacy and safety of compound azintamide and trimebutine maleate in the treatment of functional dyspepsia （FD） in elderly patients. METHODS： 48 elderly patients with FD up to Rome III were randomly divided into two groups. Treatment group were given 200 mg trimebutine maleate rid at 15 min before meal and 2 pieces of compound azintamide rid after meal for 4 weeks （n=23）. Control group were given 200 mg trimebutine maleate tid for 4 weeks （n=25）. Questionnaire survey was applied to detect the index of dyspeptic symptoms and drug toxity before and after treatment. RESULTS： The patients with FD in two groups were matched well in respect of age, sex and index of dyspeptic symptoms. Routine therapy was achieved and adverse reaction wasn＇t found. Curative efficacy and symptom score in treatment group were significantly better than in control group after 4 weeks of treatment, such as poor appetite, abdominal distension, early satiety, belching , except upper ab dominal pain and burning sensation （P〈0.05）. CONCLUSION： Compound azintamide and trimebutine maleate shows good effect on improvement of functional dyspepsia in elderly patients without serious adverse reaction.