Diazepam restores the increased [3H]glutamate binding to hippocampal synaptic membranes in the amygdaloid-kindled rat |
| |
| Authors: | J Oka M Yamada M Goto H Fukuda |
| |
| Institution: | 1. Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55414, USA;2. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55414, USA;3. Center for Orphan Drug Research, University of Minnesota, Minneapolis, MN 55414, USA;4. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55414, USA |
| |
| Abstract: | 3H]Glutamic acid binding to hippocampi was increased after amygdaloid kindling in rats, and diazepam inhibited this increased binding, without any effect on the enhanced binding by CaCl2 or the binding in control rats. By inducing kindling in the same way as that used in the binding experiment, the inhibiting effects of diazepam on kindled seizures, the afterdischarge and the development of kindling were observed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
