慢性粒细胞白血病患者预后的判断和观察

目的 :研究慢性粒细胞性白血病患者的预后因素。方法 :采用 Hasford等提出的慢性粒细胞白血病(CML)患者预后公式 ,对 5 7例 CML患者的预后进行回顾性分析。结果 :高、中、低危组比例分别占 12 .3%、40 .3%和47.4%。低危组的 5 a生存率 (4 8.5± 9.4) % ,中危组为 (93.1± 1.1) % ,而高危组患者 5 a内全部死亡 ,其 3a生存率仅 (19.3± 6 .90 ) % ,三组之间差异有显著性 (P<0 .0 1)。三组的生存曲线在 2 a后明显分开。结论 :Hasford预后评分系统能较好预测 CML 患者的预后。在影响预后的因素中 ,脾脏肿大和外周血原始细胞对于预后判断的意义较大。

PROGNOSTIC ESTIMATION AND OBSERVATION OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA

Objective:To study the prognostic factors of chronic myeloid leukemia(CML).Methods:Retrospective analysis of 57 cases of CML was conducted using a prognostic scoring system developed by Hasford et al. Results: The high risk group consisted of 7 patients (12.3%)without a case of 5 year survival,the intermediate risk group was made up of 23 patients(40.3%) with a 5 year survival rate of 39.1% and the low risk group consisted of 27 patients (47.4%) with a 5 year survival rate of 48.5%.Conclusion:The scoring system could distinguish three risk groups significantly and separate survival curves well two years later,indicating that Hasford's scoring system could assess the prognosis of patients with CML better than earlier system.Of the prognostic factors,spleen size and percentage of blasts in peripheral blood might be more important in prognostic estimation.